Leigh syndrome is a severe neurological disorder that usually becomes evident in the first year of life. This condition is characterized by gradual loss of mental and movement abilities (psychomotor regression) and results in death within two to three years, usually due to respiratory failure. It begins in infants between the ages of three months and two years. Rarely, it occurs in teenagers and adults. Symptoms may include loss of previously acquired motor skills, loss of appetite, vomiting, irritability, and/or seizure activity.
HOW IS LEIGH SYNDROME DIAGNOSED?
The general physician may perform a thorough clinical evaluation of the symptoms along with some specialized tests such as MRI and CT scan of the brain to confirm the condition.
HOW IS LEIGH SYNDROME TREATED?
There are no proven therapies for Leigh Syndrome of any type. Treatment recommendations are based primarily on open label studies, case reports, and personal observations. Treatment may require the coordinated efforts of a team of specialists. Pediatricians, cardiologists, neurologists, specialists who assess and treat hearing problems (audiologists), eye specialists, and other health care professionals may need to systematically and comprehensively plan an effective child’s treatment. The most common treatment for Leigh's disease is thiamine or Vitamin B1. Oral sodium bicarbonate or sodium citrate may also be prescribed to manage lactic acidosis. In individuals who have the X-linked form of Leigh’s disease, a high-fat, low-carbohydrate diet may be recommended
DID YOU KNOW?
Leigh Syndrome is, as a matter of fact, suggested by clinical findings and confirmed with laboratory and genetic testing.