Langerhans Cell Histiocytosis is the most common of the histiocytosis disorders. This disease occurs when the body accumulates many immature Langerhans Cells. These cells are like white blood cells that help fight infection. Too many Langerhans Cells cause tumours and damage organs. Symptoms are:
• General feeling of ill health
• Weight loss
• Single or multiple bone lesions
• Respiratory failure in severe cases
• Skin lesions
• Chest pain
• Coughing up blood
HOW IS LANGERHANS CELL HISTIOCYTOSIS DIAGNOSED?
A diagnosis of LCH may be suspected from a thorough clinical evaluation and a detailed patient history. A diagnosis may be confirmed by surgical removal and microscopic examination of affected tissue called biopsy. More tests, such as additional biopsies, blood tests, x-rays of the chest, and CT scans are performed to determine the extent of the disease.
HOW IS LANGERHANS CELL HISTIOCYTOSIS TREATED?
The treatment and its prognosis depend on the age of the child and the spread of the disease. Steroids and chemotherapy drugs are used for treatment. Radiation and surgery may be needed based on the specific condition.
DID YOU KNOW?
Historically, Langerhans Cell Histiocytosis was thought of as a cancer-like condition but recently, studies suggest that Langerhans Cell Histiocytosis is an autoimmune phenomenon.