""It is the disorder of the protein, alpha - 1- antitrypsin an autosomal dominant hereditary disorder. It leads to a chronic uninhibited tissue breakdown. This causes the degradation of lung tissue and leads to characteristic manifestations of pulmonary emphysema. Cigarette smoking is one of the main causes. The symptoms are: 1. Reduced ability to exercise 2. Wheezing (like in case of asthma) 3. Chronic cough 4. Breathing problems""
HOW IS ALPHA-1-ANTITRYPSIN DIAGNOSED?
A specialist in the Pulmonologist department can diagnose the condition with the help of tests like the Alpha 1 Foundation as well as Protein Electrophoresis. Also, methods like nephelometric and immunoturbidimetric can be used to detect this deficiency.
HOW IS ALPHA-1-ANTITRYPSIN TREATED?
Lung affected patients are treated by intravenous infusion of alpha - 1- antitrypsin derived from donated human plasma. This is called augmentation therapy Augmentation therapy is not appropriate for liver affected patients. For such patients liver transplantation may be necessary Treatments also include inhaled forms of Alpha - 1- antitrypsin.
DID YOU KNOW?
It is estimated that 1 person in3,000-5,000 has A1AT deficiency