Post induction transplant treatment is a form of transplantation treatment practised by general surgeons to treat Acute Myeloid Leukaemia (AML). This form of treatment is usually given to patients who have undergone the remission or induction therapy. Following the remission therapy, if no further treatment is given, chances of recurring AML is fairly high. This is exactly wherein post induction transplantation comes into play. The primary objective of this procedure is to completely destroy the bone marrow that contains cancerous cells which cannot be detected by any medical test, whatsoever. During the procedure, a doctor removes the cancer affected bone marrow and replaces with specialized stem cells (hematopoietic stem cells) that develop into a healthy bone marrow. The entire process takes approximately 3 – 4 hours of time to be completed.
Depending on the source from where the replacement stem cells are taken, there are two types of stem cell transplantation: allogeneic transplantation and autologous transplantation. While the allogenic form of transplant uses hematopoietic stem cells of a donor, the autologous form of treatment uses the patient's own stem cells. Allogenic form of transplantation is generally used for AML.
In certain cases, the doctor may suggest certain immunosuppressive therapy or anti-rejection drugs that reduce the strength of a patient's immune system, thus making his/ her body less likely to reject the transplanted stem cells. Apart from stimulating the body's capacity to accept the transplanted organ, anti-rejection drugs do also help in treating autoimmune disorders such as lupus, psoriasis, and rheumatoid arthritis.
As far as the treatment cost is concerned, post induction transplantation treatments are expensive. However, the average cost of autologous transplant is around $350,000, and that of an allogeneic transplant is around $800,000.
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