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Dr. P.M. Kumbhat

Dentist, Mumbai

Dr. P.M. Kumbhat Dentist, Mumbai
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My experience is coupled with genuine concern for my patients. All of my staff is dedicated to your comfort and prompt attention as well....more
My experience is coupled with genuine concern for my patients. All of my staff is dedicated to your comfort and prompt attention as well.
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Dr. P.M. Kumbhat is a renowned Dentist in Mumbai, Mumbai. You can meet Dr. P.M. Kumbhat personally at Bombay Hospital & Medical Research Centre in Mumbai, Mumbai. Save your time and book an appointment online with Dr. P.M. Kumbhat on Lybrate.com.

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Dengue Vaxia

M.B.B.S,C.C.A,D.C.A,AASECT,FPA,AAD,M.I.M.S
General Physician,
Dengue Vaxia

Dengvaxia - first vaccine against dengue

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Read more:

Dengue symptoms and what to do if you think you have denguedengue fever - remedies using papaya leaf juice

Full prescribing info - dengvaxia

Contents

Dengue tetravalent vaccine (live, attenuated).

Indications / uses

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Dosage / direction for use

The patient will receive 3 injections of 0.5 ml each at 6-month intervals.

The first injection will occur at the chosen or scheduled date; the second injection, 6 months after the first injection; and the third injection, 6 months after the second injection. Dengvaxia should be used according to the local vaccination schedule.

If the patient forgot an injection of dengvaxia: if the patient missed a scheduled injection, the physician will decide when to give the missed injection.

It is important that the patient follows the instructions of the physician, pharmacist or nurse regarding return visits for the follow-up injection. If the patient forgets or is not able to go back to the physician, pharmacist or nurse at the scheduled time, ask the physician, pharmacist or nurse for advice.

Administration: dengvaxia is given by the physician or nurse as an injection underneath the skin (subcutaneous route) in the upper arm.

Contraindications

Do not use dengvaxia if the patient is allergic (hypertensive) to the active substances or any of the other ingredients of dengvaxia listed in description (see description); has developed an allergic reaction after prior administration of dengvaxia. Signs of an allergic reaction may include an itchy rash, shortness of breath and swelling of the face and tongue; is suffering from a disease with mild to high fever or acute disease. In this case, the physician will postpone the administration of dengvaxia until the patient has recovered; has a weakened immune system, for example due to a genetic defect, hiv infection or therapies that affect the immune system (for example, high-dose corticosteroids or chemotherapy); is pregnant; is breastfeeding.

Use in pregnancy lactation: dengvaxia must not be given to pregnant or breastfeeding women.

If the patient is of child-bearing stage, the patient should take the necessary precautions to avoid pregnancy for 1 month following administration of dengvaxia; is pregnant or breastfeeding, the patient thinks may be pregnant or is planning to have a baby, ask the physician, pharmacist or nurse for advice before receiving dengvaxia.

Special precautions

Inform the physician, pharmacist or nurse before receiving dengvaxia if the patient is taking an immunosuppressive treatment (prednisone or equivalent to 20 mg or 2 mg/kg for 2 weeks or more). The physician will postpone administration of dengvaxia until 4 weeks after the treatment is discontinued; has experienced any health problems after prior administration of any vaccines. The physician will carefully consider the risks and benefits of vaccination.

As with all vaccines, dengvaxia may not protect 100% of persons who have been vaccinated. Vaccination with dengvaxia is not a substitute for protection against mosquito bites. The patient should take appropriate precautions to prevent mosquito bites, including the use of repellents, adequate clothing, and mosquito nets.

Fainting, sometimes accompanied by falling, can occur (mostly in adolescents) following, or even before, any injection with a needle. Therefore inform the physician, pharmacist or nurse if the patient fainted with a prior injection.

Adults above 45 years of age: adults above 45 years of age should not receive the vaccine.

Driving and using machines: no data are available on the effects of dengvaxia on the ability to drive or use machines.

Use in children: children less than 9 years of age should not receive the vaccine.

Side effects

Like all medicines, dengvaxia can cause side effects, although not all patients get them.

Serious allergic reactions: if any of these symptoms occur after leaving the place where the patient received an injection, consult a physician immediately: difficulty in breathing, blueness of the tongue or lips, a rash, swelling of the face or throat, low blood pressure causing dizziness or collapse.

When these signs and symptoms occur they usually develop quickly after the injection is given and while the patient is still in clinic or physician's surgery.

Serious allergic reactions are very rare (may affect up to 1 in 10, 000 people), after receiving any vaccine.

Other side effects: the following side effects were reported during clinical studies in children, adolescents and adults (from 9 to and including 60 years of age). Most of the reported side effects occurred within 3 days after the injection of the vaccine: very common (may affect more than 1 user in 10): headache, muscle pain (myalgia), generally feeling unwell (malaise), feeling of weakness (asthenia), injection site pain, fever.

Common (may affect up to 1 user in 10): injection site reactions: redness (erythema), bruising (hematoma), swelling, and itching (pruritus).

Uncommon (may affect up to 1 user in 100): infections of the upper respiratory tract, dizziness, sore throat (oropharyngeal pain), cough, runny nose (rhinorrhea), nausea, skin eruption (rash), neck pain, hardening of skin at the injection site (injection site induration).

Additional side effects in adults (from 18 to and including 60 years of age): uncommon (may affect up to 1 user in 100): swollen glands (lymphadenopathy), migraine, joint pain (arthralgia), flu-like symptoms (influenza-like illness).

Additional side effects in children and adolescents (from 9 to and including 17 years of age: uncommon (may affect up to 1 user in 100): itchy rash (urticaria).

Reporting of side effects or any suspected adverse event: if the patient experiences any side effects after vaccination, advised to seek immediate medical attention.

By reporting side effects, it can help provide more information on the safety of the vaccine.

Click to view adr monitoring form

Interactions

Using other medicines and dengvaxia: dengvaxia may not have an optimal effect if it used at the same time as medicines that suppress the immune system such as corticosteroids or chemotherapy.

Inform the physician, pharmacist or nurse if the patient is taking or has recently taken any other vaccines or any other medicines, including medicines obtained without a prescription.

Caution for usage

Before administering any biological, the person responsible for administration must take all precautions to prevent allergic or other reactions. As with all injectable vaccines, appropriate medical treatment and supervision must always be readily available in the event of an anaphylactic reaction following the administration of dengvaxia.

Epinephrine (1: 1000) and other appropriate agents used to control immediate allergic reactions must be available to treat unexpected events such as anaphylaxis.

Dengvaxia must not be mixed with other medicinal products in the same syringe.

Dengvaxia must not be administered by intravascular injection under any circumstances.

Syncope (fainting) can occur following, or even before, any vaccination as a psychogenic response to injection with a needle. Procedures should be in place to prevent injury from falling and to manage syncopal reactions.

Separate syringes and needles, separate injection sites and preferably separate limbs must be used if any other vaccine (s) or medicinal product (s) is/are concomitantly administered.

Dengvaxia is reconstituted by transferring all the solvent (0.4% sodium chloride solution) provided in the blue-labeled pre-filled syringe into the vial of freeze dried powder with a yellowish green flip off cap. The pre-filled syringe is fitted with a sterile needle for this transfer. The vial is then gently swirled. After complete dissolution, a 0.5 ml dose of reconstituted suspension is withdrawn into the same syringe. For injection, the syringe should be fitted with the new sterile needle.

The suspension should be visually inspected prior to administration. After reconstitution, dengvaxia is clear, colorless liquid with the possible presence of white to translucent particles (of endogenous nature).

After reconstitution with the solvent provided, dengvaxia must be used immediately.

Any unused dengvaxia or waste material should be disposed of, preferably by heat inactivation or incineration, in accordance with local regulations.

Do not throw away any medicines via wastewater or household waste. Ask a pharmacist on how to throw away medicines that no longer use. These measures will help to protect the environment.

Storage

Store in a refrigerator. Do not freeze. Keep the vaccine in the outer carton in order to protect it from light.

Description

After reconstitution, one dose (0.5 ml) contains 4.5-6.0 log10 ccid50* of each serotype of the cyd dengue virus** (1, 2, 3 and 4).

* ccid50: 50% cell culture infectious dose.

** produced in serum-free vero cells by recombinant dna technology.

The powder is a white, homogenous, freeze-dried powder with possible retraction at the base, and may form a ring-shaped cake.

The solvent (0.4% sodium chloride solution) is a clear, colorless liquid.

After reconstitution with the solvent provided, dengvaxia is a clear, colorless liquid with the possible presence of white to translucent particles.

Excipients/inactive ingredients: essential amino acids including l-phenylalanine, non-essential amino acids, l-arginine hydrochloride, sucrose, d-trehalose dihydrate, d-sorbitol, trometamol, urea, sodium chloride, water for injections.

Mechanism of action

Dengvaxia contains dengue virus serotypes 1, 2, 3 and 4 that have been weakened. Dengvaxia works by stimulating the body's natural defenses (immune system), which produces its own protection (antibodies) against the viruses that cause dengue disease.

Dengue is a viral infection transmitted to humans through the bite of an infected aedes mosquito. Dengue is not transmitted directly from person-to-person. Nevertheless the virus which replicates in an infected individual can be transmitted to other humans through mosquito bites for 4-5 days (maximum 12 days) after the first symptoms appear.

Dengue disease results in a wide range of symptoms including fever, headache, pain behind the eyes, muscle and joint pain, nausea, vomiting, swollen glands or skin rash. Symptoms usually last for 2-7 days. Dengue disease can also be asymptomatic.

However, occasionally dengue can be severe and potentially lead to hospitalization and in rare cases to death. Severe dengue is characterized by high fever and any of the following symptoms: severe abdominal pain, persistent vomiting, rapid breathing, severe bleeding, bleeding in stomach, bleeding gums, fatigue, restlessness, coma, seizure and organ failure.

Source:- http://www.mims.com/philippines/drug/info/dengvaxia

More information about dengvaxia - first vaccine against dengue

Sanofi awaits govt approval to launch dengue vaccine in india

Sanofi pasteur - dengue vaccine frequently asked questions

13 people found this helpful

I have cavity in my teeth. If decayed teeth affect on health. Any problem for health from cavity.

MDS Prosthodontics, BDS
Dentist, Kolkata
I have cavity in my teeth. If decayed teeth affect on health. Any problem for health from cavity.
In certain health conditions specially in patients with existing heart conditions having a infected tooth or gums can have ill effects. It's always better to have infection free mouth for overall better health.
1 person found this helpful
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Two of my teeths are got unclean from my childhood. How to get back them? Please advise.

MDS - Orthodontics, BDS
Dentist, Gandhidham
Two of my teeths are got unclean from my childhood. How to get back them? Please advise.
Around 14 years of age all deciduous teeth was fallen and all new teeth came. So kindly go for dental check up.
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Is kissing and licking vagina of my wife is healthy. Secretions occurring in vagina can go in my mouth.

BDS, D.pharm
Dentist, Chennai
Is kissing and licking vagina of my wife is healthy. Secretions occurring in vagina can go in my mouth.
It is not healthy if you not sure about the virginal secretion of your wife. First get her blood test done and if all fine then you can do what ever you want without any fear. But yes there are many bacteria that's very bad if it enters from virgina to your mouth you may have to face those bacterial and fungal infections in your mouth later.
1 person found this helpful
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BDS, PGDFO
Dentist, Gadchiroli
To remove those irky coffee and wine stains from your teeth, brush baking soda on your teeth twice a month and get that shine back.
3 people found this helpful

How teeth become yellowish colour and blush teeth every daily and take to blush teeth 8/9 blush teeth.

MDS Prosthodontics, BDS, Medicine
Dentist, Mohali
Please get scaling & polishing done first followed by bleaching. Your teeth will regain its white color again!
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No More Bleeding Gums

PERIODONTIST, B.D.S.
Dentist, Navi Mumbai
No More Bleeding Gums

Nowadays, bleeding gums is a very common problem. Many people complain of bleeding during brushing and sometimes it is without brushing. If you want a solution to this problem then first we have to work on the problem. The common cause of poor gums is food debris or plaque accumulation on the teeth. This plaque if not removed through regular brushing and dental appointments, will harden into what is known as Tartar. ultimately, this will end into inflamed gums which are prone to bleeding.

The other causes for bleeding gums consist of -

Brushing too hard
Improper flossing
Scurvy ( vitamin C deficiency)
Vitamin K deficiency
Hormonal changes during pregnancy
Use of blood thinners

Healthy tips for it:

Brush twice in a day
Rinse your mouth after every snack
Use soft bristle toothbrush and avoid excessive force during brushing
Use proper technique for dental flossing
Go for regular dental check up to avoid future complications

1 person found this helpful

Sir I am 18 years old. My face is swollen from jaws sides. Medicines prescribed by doctors are not working. please help me. What can I do to avoid this?

BDS
Dentist, Amritsar
Sir I am 18 years old. My face is swollen from jaws sides. Medicines prescribed by doctors are not working. please he...
2 things will b there 1- erupting wisdom molar which cause pericoronitis means infection in gums due lodgement of food 2- a carious tooth which cause abcess and swelling. If 2nd problem is there, you have to go for rct and drainage of pus.
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Sir I have a teeth problem in my mouth my one teeth which is not in right place, that is towards front from all teeth and it also seems danger please help me and someone said me that this teeth will also effect your eyes so what can I do sir ? please suggest me.

MDS, BDS
Dentist, Guntur
Sir I have a teeth problem in my mouth my one teeth which is not in right place, that is towards front from all teeth...
Hi. You can always get a cosmetic correction done for the tooth by using braces. Visit your nearest dentist for a proper analysis and treatment of your condition.
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Odor smell is coming from my mouth. I want to get rid of bad smell that comes from my mouth. What should I do?

Certified Implantologist, BDS
Dentist, Mumbai
Odor smell is coming from my mouth. I want to get rid of bad smell that comes from my mouth. What should I do?
You need to get scaling (cleaning) done so as to remove all the plaque and calculus, the gum bleeding, pus (if any) and bad breath would regress over a period of 10-15 days. Also do clean your tongue properly and use a good mouthwash as well.
1 person found this helpful
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I am 52 years old and I have cut marks around two years on my tongue and it is very itching when taking some spicy food. What is it and how I can overcome this problem. Please advice me.

BHMS
Homeopath, Raebareli
Please note that it could be leukoplakia due to bad-chewing habit of pan-masala etc. Please note that it could be a serious issue and a mild form/early stage of cancer even - unless otherwise proven Please take Belladonna 30 - twice daily 4 pills for next 2 weeks You need a through and proper treatment for the said issue.
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I got a wisdom tooth but it has not completely come out as there is no space for it to come out as its covered with gums. Due to that got pus as well as swelling. I consulted few dentist & they said to remove the tooth n a surgery is required as they have to cut the bone.

BDS
Dentist, Mumbai
Wisdom teeth which are not fully erupted in the mouth due to lack of space can get infected. They need to be surgically removed by cutting the tooth into pieces. Bone removal if required should be minimum.For further details, you may consult me.
1 person found this helpful
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When i had some chilled and hot food that time my teeth is pain. What should I do?

BDS (GOLD MEDALIST)
Dentist, Jamshedpur
When i had some chilled and hot food that time my teeth is pain. What should I do?
Your hypersensitivity problem in your tooth .How many days you have this? use Thermoseal RA toothpaste twice or thrice daily for 15 days .You will get relief.and advised to go for a detailed checkup. You can consult me .
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My teeth are being yellow since last few months. Please tell me what should I do to whiten my teeth again?

BDS
Dentist, Kolar
My teeth are being yellow since last few months. Please tell me what should I do to whiten my teeth again?
Naturally our teeth colour ranges from pearly white to pale yellow so everyone cannot hv white teeth. Get scalling n polishing done by dentist. If you r not happy with your teeth shade later, you can get bleaching done by dentist which'll lighten your teeth by 2-3 shades. Alternatively you can use a teeth whitening toothpaste such as snowdent after scalling. Whitening gels used daily along with customized dental trays provided by dentist r also available in the market. Avoid heavily coloured foods, tea n coffee, cool drinks, smoking n tobacco products as they stain teeth.
1 person found this helpful
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I m feeling painful when I go to the bath so pls tell me what should I do. And also I have problem in my mouth white patches are comes in every 2 3 months.

MDS
Dentist,
Dear lybrate-user, please specify the area of pain and nature of pain so we can identify the problem. White patches can be indication of vitamin deficiencies or fungal infection. Consult and after clinical examination a diagnosis can be provided.
1 person found this helpful
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Hai I am 26 years old, in an accident I lost my teeth, I heard that we can regenerate teeth using stemcells of wisdom tooth, is it possible, if it is possible how much the cost will be per tooth. I have already a bridge, but I want natural looking teeth, and I know about dental implants, but I do not want to put artificial things in my mouth.

MDS
Dentist, Wardha
Hai I am 26 years old, in an accident I lost my teeth, I heard that we can regenerate teeth using stemcells of wisdom...
Hello regeneration of teeth using stem cells is under research and study. As of now that technique is not available, may be in another 10 years or so it may be possible. Hope that it answers your question.
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Sir I am 47 years old and suffering with leukoplakia in left chick (inner v). Homeo, ayurveda and allopathic medicine used but not effectively cured.

BDS (GOLD MEDALIST)
Dentist, Jamshedpur
First you have to quit the habit of gutkha, tobacco products, alcohol and smoking if you take these. Because these things causes leukoplakia. Consult a good dental surgeon for thorough investigation and screening for any transformation. It is a precancerous stage.
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Sir I have pain in my mouth regureller, when I do tooth brush in morning. What should I do?

MDS - Oral & Maxillofacial Surgery
Dentist, Chennai
Sir I have pain in my mouth regureller, when I do tooth brush in morning. What should I do?
- Use a soft toothbrush -- and brush properly! Brush your teeth for at least two minutes twice a day and after meals. Hard brushing can further damage the soft tissues of your mouth. - Floss at least once a day and be sure to floss beyond the gum line to remove more plaque. - Control bleeding by applying pressure to the area with a cold compress. - Rinse with salt water or hydrogen peroxide to keep the area clean. Avoid mouthwashes that contain alcohol, which can dry out your mouth. - Stay away from smoking and other tobacco products, which can aggravate bleeding gums. - Eat a balanced diet and limit snacking between meals. Carbohydrates and sugars feed dental plaque. - Try an oral irrigation device, commonly known as a "water pick," to clear debris from around the gum line. - Have your dentures aligned as needed. - You may need deep cleaning along with surgical curettage or gum strengthening procedure. Use pepsodent tooth paste & gum paint for 2 to 3 weeks. Advance procedures can be done with laser. You may consult me in person.
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I am suffering from fever and throat infection and teeth pain from 4 days. What can I do for dis?

BDS
Dentist, Bangalore
I am suffering from fever and throat infection and teeth pain from 4 days. What can I do for dis?
It looks like infection due to decay on tooth. You have to go for root canal treatment. Visit to a dentist for examination and proper treatment.
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