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Overview

Paraquin DS 500mg Tablet

Manufacturer :  Shreya Life Sciences Pvt Ltd
Medicine Composition :  Chloroquine
Prescription vs OTC : Prescription by Doctor required

About Paraquin DS 500mg Tablet

Paraquin DS 500mg Tablet is an anti-malarial medication to prevent and treat malaria, a disease caused by parasites in countries where malaria is common. It works by interfering with the growth of parasites in the red blood cells of the human body.

Paraquin DS 500mg Tablet is also used to treat infections caused by amoebae occurring outside of the intestines, lupus erythematosus and rheumatoid arthritis. It is administered orally. The functioning of the liver and blood cell count should be checked from time to time while taking this medicine.

This medicine is not recommended in patients with the eye or ear disease and who have faced serious allergic reactions to any antimalarials in the past. It is not known if the medicine can cause harm to a baby so it is a safer option to not take this medicine during pregnancy or breastfeeding. Discus with your doctor the risks of taking this medication if you suffer from :

Common side effects include muscle problems, diarrhoea, loss of appetite, and skin rashes. Some serious side effects may include problems with vision, low blood cell levels, muscle damage and seizures.

Usual initial dosage for acute malaria and hepatic amoebiasis in adults is 600 mg, then dose is decreased to 300 mg a day. For severe malaria, 25 mg/kg should be given in several infusions over 30-32 hr. Paraquin DS 500mg Tablet should be taken with food.

Ensure that the course of treatment is completed before discontinuing the doses to prevent the spread of infection. The effect of this medicine can be observed in 1 to 2 hours and lasts for an average duration of 9 to 15 days

Symptoms of overdose include headache, visual changes, cardiovascular collapse, seizures, abdominal cramps, vomiting, cyanosis, methemoglobinemia, leukopenia, respiratory and cardiac arrest. Following initial measures (immediate GI decontamination), treatment is supportive and symptomatic.

It is important to complete full course of therapy which may take up to 6 months for full effect. May be taken with meals to decrease GI upset and bitter aftertaste. Avoid alcohol. You should have regular ophthalmic exams (every 4-6 months) if using this medication over extended periods.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the uses of Paraquin DS 500mg Tablet

    • Malaria Prophylaxis

      Paraquin DS 500mg Tablet is used as prophylaxis for malaria.

    • Malaria

      Paraquin DS 500mg Tablet is used in the treatment of malaria characterized by muscle pain, fever with chills and fatigue.

    • Amebiasis

      Paraquin DS 500mg Tablet is used in the amebiasis which is a parasitic infection that affects the intestine and amebic liver abscess caused by Entamoeba histolytica.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the contraindications of Paraquin DS 500mg Tablet ?

    • Allergy

      Not recommended in patients with known allergy to 4-aminoquinoline compounds.

    • Retinal Or Visual Field Changes

      Not recommended in patients with any vision impairment.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the side effects of Paraquin DS 500mg Tablet ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Key highlights of Paraquin DS 500mg Tablet

    • How long is the duration of effect?

      The effect of this medicine lasts for an average duration of 9 to 15 days.

    • What is the onset of action?

      The effect of this medicine can be observed in 1 to 2 hours.

    • Are there any pregnancy warnings?

      This medicine is not recommended in pregnant women unless absolutely necessary.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Are there any breast-feeding warnings?

      This medicine is known to excreted through breast milk. It is not recommended in for breastfeeding women.

    • Is It safe with alcohol?

      It is not known whether this medicine is safe to be consumed with alcohol. Please consult your doctor.

    • Is it safe to drive while on this medicine?

      This medicine causes side effects that affect the alertness of the patient. Thus patient must avoid driving if taking this medicine.

    • Does this affect liver function?

      Caution must be taken in patient with liver disease. Adjustment of dose might be needed. Kindly consult your doctor before taking it.

    • Does this affect kidney function?

      Caution must be taken in patient with kidney disease. Adjustment of dose might be needed. Clcr <10 mL/minute: Administer 50% of dose. Hemodialysis: Minimally removed by hemodialysis. Kindly consult your doctor before taking it.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the substitutes for Paraquin DS 500mg Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Paraquin DS 500mg Tablet , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      If you miss a dose of Paraquin DS 500mg Tablet, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Where is the Paraquin DS 500mg Tablet approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    How does this medication work?

    This medication falls under the category of an antimalarial drug that works by inhibiting the enzyme heme polymerase which prevents the conversion of the toxic heme molecules to the nontoxic hemozoin, in parasites that cause malaria. The toxic heme accumulates leading to the death of the parasite.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

      What are the interactions of Paraquin DS 500mg Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Alcohol

        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test

        Information not available.
      • Interaction with Medicine

        Ethambutol

        These medicines may increase the risk of nerve damage if given together. Any symptoms of numbness, tingling or burning sensation in feet, hands should be informed to the doctor. An alternate medicine should be considered based on the clinical condition.

        Fluconazole

        These medications may increase the risk of irregular heart rhythm. Inform the doctor if you are receiving any heart medications. Close monitoring of heart function is necessary. Discontinue the treatment if you develop any symptoms of palpitations, dizziness, and difficulty in breathing.

        Tramadol

        These medications may increase the risk of seizures if taken together. Inform the doctor if you are having any history of seizures or head injury. Any symptoms of seizures should be reported to the doctor. An alternate class of medication should be considered based on the medical condition.

        Quinidine

        These medications may increase the risk of irregular heart rhythm. Inform the doctor if you are receiving any heart medications. Close monitoring of heart function is necessary. Discontinue the treatment if you develop any symptoms of palpitations, dizziness, and difficulty in breathing.
      • Interaction with Disease

        Oculotoxicity

        This medicine is not recommended in patients with the eye disorder. Close monitoring of eye function is necessary. The treatment should be discontinued if any symptoms of blurred vision, difficulty in reading appear.

        Other diseases

        Use with caution in patients with liver disease, G-6-PD deficiency, alcoholism or in conjunction with hepatotoxic drugs, psoriasis, porphyria may be exacerbated; retinopathy (irreversible) has occurred with long or high-dose therapy; discontinue drug if any abnormality in the visual field or if muscular weakness develops during treatment.
      • Interaction with Food

        Information not available.

      FAQs about Paraquin DS 500mg Tablet

      • Ques : What is Paraquin DS 500mg Tablet?

        Ans : Paraquin DS 500mg Tablet is an antiparasitic medication which helps to cure malaria.

      • Ques : What are the uses of Paraquin DS 500mg Tablet?

        Ans : This drug is used to treat malaria. It helps by increasing heme levels in the blood.

      • Ques : What are the side effects of Paraquin DS 500mg Tablet?

        Ans : This drug can cause problems like Rash, Headache, Dizziness, Vomiting, Nausea, Stomach pain and Itching in some individuals.

      • Ques : Is Paraquin DS 500mg Tablet available over the counter?

        Ans : Yes, this drug is available over the counter medicine.

      • Ques : Is Paraquin DS 500mg Tablet safe in G6PD deficiency?

        Ans : This drug is not suitable for those who have G6PD deficiency. Consult your doctor before taking it or prefer some other alternative.

      • Ques : Is Paraquin DS 500mg Tablet banned in Nigeria?

        Ans : Yes, it is banned in Nigeria.

      • Ques : What is the Lariago tablet/Lariago syrup/Lariago-DS/ Resochin used for?

        Ans : All of them are the trade names by which Paraquin DS 500mg Tablet is available in the market.

      • Ques : Does Paraquin DS 500mg Tablet affect birth control/ affect the birth control pill/contraceptive pill/ menstrual cycle?

        Ans : This drug does not affect the functioning of birth control or contraceptive pill/ menstrual cycle. In case you observe any such side effect, consult a doctor on an immediate basis.

      • Ques : Does Paraquin DS 500mg Tablet cause nightmares/insomnia?

        Ans : Paraquin DS 500mg Tablet can cause few side effects, however, nightmares or insomnia is a very rare side effect of this drug. Please consult a doctor if you have this symptom.

      References

      • Chloroquine-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/chloroquine

      • Chloroquine-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 2 June 2022].Available from:

        https://go.drugbank.com/drugs/DB00608

      • CHLOROQUINE injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 2 June 2022].Available from:

        https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=CHLOROQUINE

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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