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Overview

Fibroease 25 MG Tablet

Manufacturer: Akumentis Healthcare Ltd
Medicine composition: Mifepristone
Prescription vs.OTC: Prescription by Doctor required

Fibroease 25 MG Tablet is used to bring about an abortion in women who have been pregnant for about seven weeks or 50 days. It is used in combination with misoprostol. Fibroease 25 MG Tablet is also known as RU-486. Fibroease 25 MG Tablet is a synthetic steroid which functions by interfering with the hormone that helps pregnancy to continue.

On using Fibroease 25 MG Tablet you may experience some side effects. These reactions include vaginal bleeding, constant feelings of fatigue, chest pain, cough, fever, body sores, difficulty in urination, difficulty in breathing, sweating, diarrhea, anxiety, vomiting, nausea, lightheadedness, increased abdominal pain, paleness, tremors, insomnia, weakness, acidity and indigestion.

Before taking Fibroease 25 MG Tablet you should have a discussion with your doctor and tell him if you have any of the conditions mentioned below:

  • You are allergic to any of the ingredients contained within Fibroease 25 MG Tablet or any other medicine.
  • You are pregnant outside your uterus region.
  • You are taking any anticoagulants.
  • You are taking any prescriptive or non-prescriptive drugs, herbal medications, dietary supplements.
  • You are going to undergo anesthesia anytime soon.
  • You are older than 35 years.
  • You smoke 10 or more cigarettes.
  • You have asthma, liver, kidney or lung diseases.

The dosage for Fibroease 25 MG Tablet is prescribed by your doctor depending on your age, weight, overall health and current condition. The usual dose in case of abortion is about 200 mg orally once. From day two or three, the dosage is about 800 mcg every 24 or 48 hours. While taking Fibroease 25 MG Tablet you are meant to put the tablets in each cheek pouch and keep it there for around half an hour. Should any remnants remain, swallow it with water. After 7 days, you are required to visit your doctor to check if you are still pregnant and also to monitor the quantity and frequency of the bleeding.

Fibroease 25 MG Tablet is used for terminating pregnancies which are less than 10 weeks old. It is also used for labor induction in case of fetal death or before surgical procedures are performed to terminate a pregnancy.
Cushing's syndrome
Fibroease 25 MG Tablet is used for managing elevated blood sugar levels in patients having Cushing's syndrome coupled with type 2 diabetes mellitus or glucose intolerance.type diabetes
This medicine is not recommended for use if you have a known history of allergy to it or any other medicine that are classified under the category of prostaglandin analogue.
This medicine is not recommended for termination of pregnancy in women who are suspected to have the fertilized egg to be present outside the uterus (Ectopic pregnancy).
Current use of intra-uterine device
This medicine is not recommended for use in women who have an intra-uterine device in place.
Chronic adrenal failure
This medicine is not recommended for use if you have a long term adrenal gland malfunction.
Corticosteroids
This medicine is not recommended for use in patients who are using Corticosteroids for serious conditions like immune system disorder.
Unexplained vaginal bleeding
This medicine is not recommended for use in women who have an active or historic case of severe and unexplained vaginal bleeding. The bleeding may be intermittent and after the menopause indicative of uterine cancer.
Other bleeding disorders
This medicine is not recommended for use in patients who have a bleeding disorder and are receiving anticoagulants for the same.
This medicine is not recommended for use in patients having this inherited disorder of the disease of the blood affecting the nervous system and skin (Porphyria).
In addition to its intended effect, Fibroease 25 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Heavy vaginal bleeding Major Less Common
Infections Major Rare
Unusual tiredness and weakness Major Less Common
Abdominal pain and cramps Moderate Common
Uterine cramping Moderate Common
Nausea and Vomiting Moderate Common
Headache Moderate Common
Dizziness Moderate Common
Diarrhea Minor Common
Pain in the arms and legs Minor Less Common
Decreased appetite Minor Rare
Sleeplessness Minor Rare
Difficult or painful urination Major Rare
Loss of strength Minor Less Common
Difficult and painful breathing Moderate Rare
How long is the duration of effect?
The effect of this medicine lasts for an average duration of 7-10 days.
What is the onset of action?
This medicine is rapidly absorbed into the bloodstream upon oral administration and reaches the peak levels within 1-2 hours.
Are there any pregnancy warnings?
The use of this medicine is acceptable for medical termination of intrauterine pregnancy which is 63-70 days old. However, use of this medicine for control of elevated blood sugar levels along with elevated cortisol level is not recommended for pregnant women. It should be noted that a failed attempt to terminate pregnancy might result in severe complications.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
The use of this medicine should be avoided by women who are breastfeeding. However, if it becomes necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor regarding the potential benefits and risks involved before taking this medicine.
Missed Dose instructions
Take the missed dose as soon as you remember if the intended use is to control elevated blood sugar levels. If it is almost time for the next scheduled dose then the missed dose should be skipped. For medical termination of pregnancy, it is a single dose therapy and hence missing a dose is not possible.
Overdose instructions
Contact your doctor and seek immediate help if an overdose with mifepristone is suspected.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Disease
Information not available.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Grapefruit juice Moderate
Avoid the consumption of large quantities of grapefruit juice while taking mifepristone as it can alter the levels of this medicine in the blood.
Interaction with Medicine
Dexamethasone Major
Use of dexamethasone with mifepristone is not recommended. If it is absolutely necessary to use these medicines together then suitable dose adjustments and clinical safety monitoring are recommended. Report the use of either of the medicine to the doctor so that the best course of treatment could be determined.
Erythromycin Major
Report the use of erythromycin to the doctor before receiving Fibroease 25 MG Tablet. The risk of adverse effect on heart and electrolyte levels in the body are significantly high when these medicines are used together. Your doctor may determine the best course of treatment in such cases.
Hydrocortisone Major
Using hydrocortisone with mifepristone is generally not recommended. Report the use of this medicine before receiving mifepristone. Your doctor may determine the best course of treatment in such cases. Do not stop the use of any medicine without consulting your doctor.
Ketoconazole Major
Report the use of either of the medicine to the doctor. In order to decrease the risk of adverse effects, you may a require a dose adjustment and more frequent monitoring. Do not stop the use of any medicine without consulting your doctor.
Simvastatin Major
Report the use of simvastatin to the doctor before receiving mifepristone. The risk of adverse effects is significantly high when these medicines are used together. Your doctor may ask you to temporarily stop the use of Simvastatin till the course of Fibroease 25 MG Tablet is completed.
Pimozide Major
Report the use of pimozide to the doctor before receiving Fibroease 25 MG Tablet. The risk of adverse effect on heart and electrolyte levels in the body are significantly high when these medicines are used together. Your doctor may determine the best course of treatment in such cases.
Warfarin Major
Report the use of warfarin or any other medicine used for bleeding disorders to the doctor before receiving mifepristone. The risk of adverse effects is significantly high in women. Appropriate precautionary measures and clinical monitoring of symptoms are recommended in such cases.
Ergotamine Major
Report the use of ergotamine to the doctor before receiving mifepristone. The risk of adverse effects is significantly high when these medicines are used together. Your doctor may ask you to temporarily stop the use of ergotamine or prescribe an alternate medicine till the course of Fibroease 25 MG Tablet is completed.
What are you using Fibroease 25 MG Tablet for?
Other
Termination Of Pregnancy
Cushing's syndrome
How much was the improvement?
Average
Poor
Excellent
How long did it take before seeing improvement?
More than 2 days
Within a day
Within 2 days
Within 2 hours
How frequently did you take this medicine?
Once a day
Not taking on daily level
Four times A Day
Thrice a day
How did you take this medicine?
With Food
With or without food
Empty stomach
What were the side effects of this medicine?
Heavy vaginal bleeding
Dizziness
Unusual tiredness and weakness
Uterine cramping
Infections
Headache
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

My doctor suggested me to use the fibroease 10 tablets for decrease the size of fibroid in uterus. Is it works?

MBBS, MS - Obstetrics & Gynecology, Fellowship in Infertility (IVF Specialist)
Gynaecologist, Aurangabad
My doctor suggested me to use the fibroease 10 tablets for decrease the size of fibroid in uterus. Is it works?
hi Ratna it depends upon size of the fibroid. studies shows that it helps to reduce size of the fibroid in70%cases.
1 person found this helpful

I have fibroid and pcos now I take fibroid tablet of fibroease for 30 days this time are we have sexual intercourse? This time sex is safe or not?

MBBS, DGO, DNB
Gynaecologist, Noida
Fibroease contains antiprogesterone (mifepristone) so there are less chances of conceiving while taking these tablets .But still backup contraception advised as it can lead to congenital anomaly in the fetus if patient conceives.

I was diagnosed with uterine fibroid 30 x 29 mm on March 2018. I was prescribed Pristal for 3 months once daily but decrease was nominal as per present TVS. 32 x21 mm. Now doc. Has prescribed fibroease 25 for three months once daily. I am 40 years wt 56 kg. Pl. Advice whether I have to go for surgery or there is any hope with the prescribed medicine. Fibroease 25.

MBBS, MS - Obstetrics and Gynaecology
Gynaecologist, Ghaziabad
I was diagnosed with uterine fibroid 30 x 29 mm on March 2018. I was prescribed Pristal for 3 months once daily but d...
At 40 years age 3 cm fibroid doesn't require active action unless there are associated symptoms .It needs to be kept under observation by 6monthly Usg. Since you have already started fibrorease take it for 3moths and RPT Usg for any reduction in size or not.
2 people found this helpful

Popular Health Tips

Choice between Surgical and Medical Abortion

MD - Obstetrtics & Gynaecology
Gynaecologist, Mumbai
There are two methods by which abortion can be done

Medical Abortion -non-surgical abortion in which medicines are used to induce abortion
Surgical Abortion - Use of transcervical procedures for terminating pregnancy, including vacuum aspiration, and dilatation and evacuation (D&E).

Surgical or Medical Abortion for Unwanted Pregnancy

If pregnancy is <= 7 weeks; medical Method with Mifepristone with misoprostol is favorable as success rate is as high as 97%.
If pregnancy is between 7-12 weeks; surgical abortion is the only option.
If pregnancy is beyond 12 weeks – 20 weeks, then woman needs to be hopsitalized and will be given either Mifepristone followed by Misoprostol tablet or only misoprostol tablets and woman will then abort like a miscarriage in the Hospital. If any products are remaining then it will be evacuated surgically.
Surgical abortion is preferred if patient desires concurrent tubal ligation or IUCD (CuT) insertion.
If a woman fulfills the criteria for selecting either method i.e. Before 7 weeks), final choice to be given to the woman.

Summary of Choice between Surgical or Medical abortion in India

<= 7 weeks – Medical method or Surgical method
7-12 weeks – Surgical abortion
12 – 20 weeks – Medicines with or without surgical procedure in Hospital.

Advantages of Medical Abortion

Avoids surgery. Controlled by the woman and may take place at home. No need for admission to the Hospital. Usually well tolerated by women if properly counselled and motivated. No need to take leave from work, as bleeding can be manged with menstrual pads even while in office or at work.

Disadvantages of Medical abortion

Takes time (hours to days) to complete abortion, and the timing may not be predictable. Women experience bleeding and cramping, and potentially some other side-effects (nausea, vomiting, fever, and shivering). May require more clinic visits than surgical abortion.

Advantages of Surgical Abortion

Quick procedure. Complete abortion easily verified by evaluation of aspirated products of conception. Takes place in a Hospital so Sterilization or placement of an intrauterine device (IUD) may be performed at the same time as the procedure. It can be performed under local anaesthesia if woman is properly motivated and counselled.

Disadvantages of Surgical abortion

Requires instrumentation of the uterus. Small risk of uterine or cervical injury. Timing of abortion controlled by the Doctor and Hospital. Anaesthesia wneeds to be administered. Most doctors perform this procedure under short general anaesthesia. Woman needs to be in the Hospital for at least 6 hours. Effect of sedation will be there throuout the day.
14 people found this helpful

Methods of Abortion for Unwanted Pregnancy

MD - Obstetrtics & Gynaecology
Gynaecologist, Mumbai
Methods of Abortion for Unwanted Pregnancy

There are two methods by which abortion can be done:

  • Medical Abortion - Non-surgical abortion in which medicines are used to induce abortion
  • Surgical Abortion - Use of transcervical procedures for terminating a pregnancy, including vacuum aspiration, and dilatation and evacuation (D and E).

Surgical or Medical Abortion for Unwanted Pregnancy

  • If pregnancy is lesser than = 7 weeks; medical method with Mifepristone with Misoprostol is favorable as the success rate is as high as 97%.
  • If pregnancy is between 7-12 weeks; surgical abortion is the only option.
  • If pregnancy is beyond 12 weeks - 20 weeks, then the woman needs to be hospitalized and will be given either Mifepristone followed by Misoprostol tablet or only Misoprostol tablets and woman will then abort like a miscarriage in the hospital. If any products are remaining, then it will be evacuated surgically.

Surgical abortion is preferred if patient desires concurrent tubal ligation or IUCD (CuT) insertion. If a woman fulfills the criteria for selecting either method i.e. before 7 weeks, final choice has to be given to the woman.

Summary of choice between Surgical or Medical abortion in India

  • Lesser than = 7 weeks - Medical method or surgical method
  • 7-12 weeks - Surgical abortion
  • 12 - 20 weeks - Medicines with or without surgical procedure in hospital

Advantages of Medical Abortion

  • Avoid surgery - Controlled by the woman and may take place at home
  • No need for admission to the hospital
  • Usually, well tolerated by women, if properly counselled and motivated
  • No need to take leave from work, as bleeding can be managed with menstrual pads even while in the office or at work.

Disadvantages of medical abortion

  • Takes time (hours to days) to complete abortion, and the timing may not be predictable. Women experience bleeding and cramping, and potentially some other side-effects (nausea, vomiting, fever, and shivering). May require more clinic visits than surgical abortion.

Advantages of Surgical Abortion

  • Quick procedure
  • Complete abortion easily verified by evaluation of aspirated products of conception
  • Takes place in a hospital so Sterilization or placement of an intrauterine device (IUD) may be performed at the same time as the procedure. It can be performed under local anaesthesia if woman is properly motivated and counselled

Disadvantages of surgical abortion

  • Requires instrumentation of the uterus
  • Small risk of uterine or cervical injury
  • Timing of abortion controlled by the doctor and hospital
  • Anaesthesia needs to be administered. Most doctors perform this procedure under short general anaesthesia. A woman needs to be in the hospital for at least 6 hours. Effect of sedation will be there throughout the day.

Related Tip: Why eating fish is essential for a healthy pregnancy??

3910 people found this helpful

Uterine Fibroids - How They Can Be Managed?

Fellowship in Gynae Endoscopy, FMAS, DNB, DGO, MBBS
Gynaecologist, Delhi
Uterine Fibroids - How They Can Be Managed?

The uterine fibroids are one of the most common gynecologic problems, with over 40-50% of women having them at some point in their life. The number and size of the fibroids, the age of onset, associated symptoms like dysfunctional bleeding and pelvic pain will determine the management of fibroid. The following is a series of management measures, starting from the most conservative to the most invasive. 

1. Wait and watch: In women who are asymptomatic, it is best to watch them for the development of symptoms without any intervention. Also, in women nearing menopause, it is best to just watch the fibroids as they just shrink once menstruation ceases. 

2. Medical therapy: In some women, menstrual cycles could be heavy or irregular and require hormonal replacement. They could also have occasional pain, and so may require painkillers. 

  1. Tranexamic acid is a non-hormonal medication that can be used on heavy bleeding days only to ease the heavy menstrual flow. 
  2. Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful in pain control. Iron and vitamin supplements are also useful in managing anemia and weakness associated with heavy bleeding. 
  3. Oral contraceptives and/or progestins are also used to control abnormal menstrual bleeding. They do not have any effect on fibroid size though. 
  4. Progestin could also be delivered through an intrauterine device (Mirena) to relieve heavy bleeding and prevent pregnancy
  5. Gonadotropin-releasing hormone (Gn-RH) agonists: They block the production of oestrogen and progesterone, and so induce a temporary postmenopausal state. This can also be used to shrink the fibroid so it is easier to remove it surgically. This is not used for more than 3 to 6 months as they can cause hot flashes and bone loss. 
  6. Newer drugs like Mifepristone and Ulipristal acetate are being used to shrink the size of fibroids. 

3. Noninvasive procedure: MRI-guided focused ultrasound surgery is when the women are inside the MRI scanner and an ultrasonic transducer is used for treatment. The exact location of the fibroids are identified and sound waves are used to destroy the fibroid. Done on an outpatient basis, it is safe and effective. 

4. Minimally invasive procedures: Uterine artery embolization is where the arterial supply is cut off to reduce fibroid growth. Myolysis is where laparoscopically heat or cold waves are used to lyse off the fibroids. Endometrial ablation is where the uterine lining is destroyed through high-intensity heat or cold waves. 

5. Invasive procedures: Abdominal or Laparoscopic myomectomy is where the fibroids are removed through an abdominal incision or keyhole surgery. If fibroids are extensive and completed family, hysterectomy is the choice of treatment. Given their high incidence, fibroids require management based on symptoms, age, and other considerations as discussed and decided between the patient and the doctor.

2640 people found this helpful

Table of Content

About Fibroease 25 MG Tablet
When is Fibroease 25 MG Tablet prescribed?
What are the contraindications of Fibroease 25 MG Tablet?
What are the side effects of Fibroease 25 MG Tablet?
Key highlights of Fibroease 25 MG Tablet
What are the dosage instructions?
Where is the Fibroease 25 MG Tablet approved?
What are the interactions for Fibroease 25 MG Tablet?