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I sleep really late and feel lethargic all day. Night time I'm most active is it because of I'm thalassemia minor? My recent hemoglobin level has dropped to 9.4 from 10.9.

I sleep really late and feel lethargic all day. Night time I'm most active is it because of I'm thalassemia minor? My...
No That wouldnt cause weakness as your body is adapted to low Hb We need to look for alternate etiology as well 1. Superadded iron deficiency 2. Hypothyroidism.
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About thalassemia major patient bone marrow transplant? Want brief treatment process and cost price. Please help.

About thalassemia major patient bone marrow transplant? Want brief treatment process and cost price. Please help.
It depends on degree of match Complications arising post transplant Conditioning regimen used for transplant etc It can be as low as 5-6 lakhs to as Hugh as 20-25 lakhs as well.
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How To Treat Thalassemia In Children?

How To Treat Thalassemia In Children?
Thalassemia is a type of a disease, resulting in the abnormal production of hemoglobin in the blood. Hemoglobin stimulates oxygen circulation all over the body. Therefore, a dip in the hemoglobin count can lead to anemia, a disease inducing weakness as well as fatigue. Acute anemia can take a toll on the organs and ultimately cause death.

Severe thalassemia in children yields symptoms, such as dark urine, abdominal swelling, slow growth, jaundice, a pale appearance and deformed skull bones. Diarrhea, frequent fevers and eating disorders are also common.


Blood transfusions: Regular blood transfusion is the only treatment needed for beta thalassemia aiming to keep sufficient Hb level to avoid long-term complications, though bone marrow transplant is radical cure for the disease.
Iron chelation therapy: The hemoglobin in the red blood cells is rich in iron-protein that gets deposited in the blood with regular blood transfusion. This condition is known as iron overload as it damages heart, liver and various parts of the body. Iron chelation therapy is used to prevent this damage as it helps to remove the excess iron from the body. Deferoxamine and Deferasirox are two such medicines used for this therapy.
Folic acid supplements: Folic acid being a B vitamin produces healthy red blood cells and is therefore recommended as a substitute for the above procedures.
Transplant of blood and marrow stem cell: A blood and a marrow (a substance within the cavities of bones where blood cells are produced) transplant replaces the faulty stem cells with healthy ones contributed by a donor.
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Thalassemia - Types, Causes And Symptoms Of It!

Thalassemia - Types, Causes And Symptoms Of It!
Thalassemia is a genetic (which is passed from parents to children through genes) blood disorder. People with Thalassemia disease are not able to make enough hemoglobin, which causes severe anemia. Hemoglobin is found in red blood cells and carries oxygen to all parts of the body. When there is not enough hemoglobin in the red blood cells, oxygen cannot get to all parts of the body. Organs then become starved for oxygen and are unable to function properly.

There are two types of Thalassemia disease

Alpha Thalassemia disease: There are two main types of Alpha Thalassemia disease. Alpha Thalassemia Major is a very serious disease in which severe anemia begins even before birth. Pregnant women carrying affected fetuses are themselves at risk for serious pregnancy and delivery complications. Another type of Alpha Thalassemia is Hemoglobin H disease. There are varying degrees of Hemoglobin H disease.
Beta Thalassemia disease: Beta Thalassemia Major (also called Cooley's Anemia) is a serious illness. Symptoms appear in the first two years of life and include paleness of the skin, poor appetite, irritability, and failure to grow. Proper treatment includes routine blood transfusions and other therapies.
Causes of Thalassemia

Thalassemia occurs when there s an abnormality or mutation in one of the genes involved in hemoglobin production. You inherit this genetic defect from your parents.

If only one of the parents is a carrier for thalassemia, the child may develop a form of the disease known as thalassemia minor. If this occurs, the born child probably won t have symptoms, but he/she will be a carrier of the disease. Some people with thalassemia minor do develop minor symptoms.

If both of your parents are carriers of thalassemia, you have a greater chance of inheriting a more serious form of the disease.


The symptoms depend on the type of thalassemia:

Thalassemia Minor: Thalassemia minor usually doesn t cause any symptoms. If it does, it causes minor anemia.
Beta-thalassemia: Beta-thalassemia comes in two serious types, which are thalassemia major, or Cooley s anemia, and thalassemia intermedia. The symptoms of thalassemia major generally appear before a child s second birthday. The severe anemia related to this condition can be life-threatening. Other signs and symptoms include:
frequent infections
a poor appetite
failure to thrive
jaundice, which is a yellowing of the skin or the whites of the eyes
enlarged organs
This form of thalassemia is usually so severe that it requires regular blood transfusions.

Alpha-thalassemia: Alpha-thalassemia also has two serious types, which are hemoglobin H disease and hydrops fetalis. Hemoglobin H disease can cause bone issues. The cheeks, forehead, and jaw may all overgrow. Hemoglobin H disease can cause:

jaundice, which is a yellowing of the skin or the whites of the eyes
an extremely enlarged spleen
Hydrops fetalis is an extremely severe form of thalassemia. It occurs before birth. Most individuals with this condition are either stillborn or die shortly after being born.

How is thalassemia diagnosed?

Thalassaemia is often detected during pregnancy or soon after birth.

Screening during pregnancy: Screening to check if a baby is at risk of being born with thalassemia is offered to all pregnant women.
Testing after birth or later in life: Newborn babies aren't routinely tested for thalassemia because the test used isn't always reliable soon after birth and the condition isn't immediately dangerous. However, the main form of the condition beta thalassemia major is often picked up as part of the newborn blood spot test (heel prick). A blood test can be carried out at any point to diagnose the condition if a child or adult has symptoms of thalassemia and the condition wasn't picked up earlier on.
Testing for the Thalassemia Trait- A blood test can be done at any time to find out if you have the thalassemia trait and are at risk of having a child with the condition. This can be particularly useful if you have a family history of the condition or your partner is known to carry thalassemia.
If your child has thalassemia, blood tests may reveal:

A low level of red blood cells
Smaller than expected red blood cells
Pale red blood cells
Red blood cells that are varied in size and shape
Red blood cells with uneven hemoglobin distribution, which gives the cells a bull's-eye appearance under the microscope
Blood tests may also be used to:

Measure the amount of iron in your child's blood
Evaluate his or her hemoglobin
Perform DNA analysis to diagnose thalassemia or to determine if a person is carrying mutated hemoglobin genes
Treatment for Thalassemia-

The treatment for thalassemia depends on the type and severity of disease involved. Your doctor will give you a course of treatment that will work best for your particular case.

Some of the utilized treatments include:

blood transfusions
a bone marrow transplant (BMT)
medications and supplements
possible surgery to remove the spleen or gallbladder
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My wife has a thalassemia trait. Her initial haemoglobin was around 8.8-8.9.but now it is hovering around that a concern? Please suggest. She is into her 32 weeks of pregnancy.

My wife has a thalassemia trait. Her initial haemoglobin was around 8.8-8.9.but now it is hovering around ...
Hi sir- in my opinion it will be better if you take our thalla and HB med course-- for permanent cure. Low Hb is of high concern to the baby even and both.
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Screening For Thalassemia Trait!

Screening For Thalassemia Trait!
Thalassemia major is a genetic disorder. Patients suffering from thalassemia major currently need life long blood transfusion and iron chelation. The only curative option available is bone marrow transplant which is not available to everyone due to lack of a matched donor.
Every year, nearly 10,000 new thalassemia major patients are born in our country. The best way to prevent thalassemia major is to get yourself and your partner screened for thalassemia trait.
Ask for thalassemia test today!
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Hi Sir, me and my girlfriend both are having thalassemia carrier. We want to marry now. Is there any problem in our sexual life? Is CVS test is reliable?

Hi Sir, me and my girlfriend both are having thalassemia carrier. We want to marry now. Is there any problem in our s...
No. Don't worry. Accuracy of the CVS Test. Chorionic villus sampling is more than 99 percent accurate when it comes to diagnosing chromosomal results, such as Down syndrome. However, there's a sliver of a chance for a false positive—when the test comes back indicating a genetic problem, but in reality, the baby is developing normally.
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Hello, hematologist, I have thalassemia major by birth I am consulting you because I want to know that is using filter with /during blood transfusion of 2 bags can help form less iron in body. Is there any advantage of using filter that forms less iron in body. I am taking transfusion every 18-20 days.

Hello, hematologist, I have thalassemia major by birth I am consulting you because I want to know that is using filte...
Hi, the filtered prbc transfusion contains same amount of iron as without​ filter. Filter are not for reduction of iron. It is used to reduce transfusion associated fever, shivering and to reduce late effect of alloimunisation, a complications which leads to future blood transfusion ineffective. For iron overload, one need to take regular oral medicine (chelation therapy). Hope it clears the confusion.
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My daughter is 18 years old thalassemia child. She has been detected combs Direct positive. Kindly advise the treatmen. Thank you.

My daughter is 18 years old thalassemia child. She has been detected combs Direct positive. Kindly advise the treatme...
As she is thalassemic, so I think, she is receiving regular blood transfusion. The direct coombs test may become positive in many situations and treatment is completely different for those. First the test may give false positive report, if done within 3 weeks of last transfusion. If it is true positive, then we need to do indirect coombs test with specific card (3 card or 11 card) to know whether it is auto immune or allo immune in nature. For details evaluation you need to contact with immuno hematologist with very good transfusion medicine lab facility. You can contact in paid online consultation for further evaluation and management protocol. Thanks.
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Thalassaemia : How To Understand It?

Thalassaemia : How To Understand It?
Thalassaemia, which is commonly referred to as thal, is a disorder of the blood which is inherited from the previous generation. This condition triggers the production of abnormal red blood cells in the body which in turn paves the way for chronic anaemia. Red blood cells play an indispensable role in carrying oxygen all through the body and hence any abnormality in this regard can result in thalassemia, the symptoms of which include, weakness all over the body, fatigue, faint and shortness of breath.

Understanding the type of thalassemia:
Thalassaemia is often thought to be an iron deficiency disease (anaemia), but can be differentiated with the aid of certain blood tests. This disease is a lifelong condition which requires efficient management. The type of thalassemia an individual is suffering from can be attributed to the number of faulty genes the person has inherited.

The two variants of thalassaemia are beta and alpha. In the case of alpha thalassemia, having one faulty gene would lead to no health problems while two faulty genes can cause mild anaemia. If there are three mutated genes, it will cause Haemoglobin H disease, and regular blood transfusions may be required. But an unborn child with four mutated genes will not be viable enough to survive the pregnancy.

The beta thalassaemia also comes in various forms. The beta thalassaemia major needs lifelong transfusion of blood and it is the most common form of thalassaemia across the world. The beta thalassemia intermedia do not have to depend on blood transfusion.

Any kind of Microcytic Anemia has to be evaluated properly with an iron profile, peripheral smear and a Hemoglobin electrophoresis, if we have evidence of hemolysis in peripheral smear.

Treating thalassaemia:
The treatment option for mild thalassaemia is entirely dependent on the type of the disease and how intense it is. When the disease is on a mild and minor level, then there may not be need of any comprehensive treatment. But at times, blood transfusions become necessary especially after undergoing surgery or when the thalassaemia causes complications.

People who are affected by severe levels of beta thalassaemia will require transfusion of blood from time to time. The treatment also causes an overload of iron and thus, it is important to remove the surplus iron content. There are several oral medications available for this, and the healthcare provider can recommend suitable medications.

Managing moderate to severe thalassaemia:
Some of the most general methods of managing and treating thalassaemia include:

Frequent blood transfusions: When the thalassaemia gets too severe, it becomes necessary to opt for blood transfusion after every few weeks. The blood transfusion can cause iron build up with the passage of time. This, in turn, can affect the heart and lungs along with other crucial organs. Therefore, it is important to take medicines that can eliminate the extra iron.
Stem cell transplant: Also referred to as the bone marrow transplant, the stem cell transplant can be the best bet. It is recommended for kids who are born with severe thalassaemia. This treatment option can mitigate the need of a lifelong transfusion of blood and intake of drugs for controlling the iron overload.
Thallasemia generally occurs in pockets like in Haryana, Punjab, Delhi, Uttar Pradesh, Chhattisgarh, etc. The concerned state units of these states need to take guidance from doctors for definite treatment which is bone marrow transplant.
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