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Hello, hematologist, I have thalassemia major by birth I am consulting you because I want to know that is using filter with /during blood transfusion of 2 bags can help form less iron in body. Is there any advantage of using filter that forms less iron in body. I am taking transfusion every 18-20 days.

DM - Clinical Haematology, MD - General Medicine, MBBS
Hematologist, Durgapur
Hello, hematologist, I have thalassemia major by birth I am consulting you because I want to know that is using filte...
Hi, the filtered prbc transfusion contains same amount of iron as without​ filter. Filter are not for reduction of iron. It is used to reduce transfusion associated fever, shivering and to reduce late effect of alloimunisation, a complications which leads to future blood transfusion ineffective. For iron overload, one need to take regular oral medicine (chelation therapy). Hope it clears the confusion.
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My daughter is 18 years old thalassemia child. She has been detected combs Direct positive. Kindly advise the treatmen. Thank you.

DM - Clinical Haematology, MD - General Medicine, MBBS
Hematologist, Durgapur
My daughter is 18 years old thalassemia child. She has been detected combs Direct positive. Kindly advise the treatme...
As she is thalassemic, so I think, she is receiving regular blood transfusion. The direct coombs test may become positive in many situations and treatment is completely different for those. First the test may give false positive report, if done within 3 weeks of last transfusion. If it is true positive, then we need to do indirect coombs test with specific card (3 card or 11 card) to know whether it is auto immune or allo immune in nature. For details evaluation you need to contact with immuno hematologist with very good transfusion medicine lab facility. You can contact in paid online consultation for further evaluation and management protocol. Thanks.
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Thalassaemia : How To Understand It?

MBBS, MD , DiP DIAB, FACP
General Physician, Bangalore
Thalassaemia : How To Understand It?
Thalassaemia, which is commonly referred to as thal, is a disorder of the blood which is inherited from the previous generation. This condition triggers the production of abnormal red blood cells in the body which in turn paves the way for chronic anaemia. Red blood cells play an indispensable role in carrying oxygen all through the body and hence any abnormality in this regard can result in thalassemia, the symptoms of which include, weakness all over the body, fatigue, faint and shortness of breath.

Understanding the type of thalassemia:
Thalassaemia is often thought to be an iron deficiency disease (anaemia), but can be differentiated with the aid of certain blood tests. This disease is a lifelong condition which requires efficient management. The type of thalassemia an individual is suffering from can be attributed to the number of faulty genes the person has inherited.

The two variants of thalassaemia are beta and alpha. In the case of alpha thalassemia, having one faulty gene would lead to no health problems while two faulty genes can cause mild anaemia. If there are three mutated genes, it will cause Haemoglobin H disease, and regular blood transfusions may be required. But an unborn child with four mutated genes will not be viable enough to survive the pregnancy.

The beta thalassaemia also comes in various forms. The beta thalassaemia major needs lifelong transfusion of blood and it is the most common form of thalassaemia across the world. The beta thalassemia intermedia do not have to depend on blood transfusion.

Any kind of Microcytic Anemia has to be evaluated properly with an iron profile, peripheral smear and a Hemoglobin electrophoresis, if we have evidence of hemolysis in peripheral smear.



Treating thalassaemia:
The treatment option for mild thalassaemia is entirely dependent on the type of the disease and how intense it is. When the disease is on a mild and minor level, then there may not be need of any comprehensive treatment. But at times, blood transfusions become necessary especially after undergoing surgery or when the thalassaemia causes complications.

People who are affected by severe levels of beta thalassaemia will require transfusion of blood from time to time. The treatment also causes an overload of iron and thus, it is important to remove the surplus iron content. There are several oral medications available for this, and the healthcare provider can recommend suitable medications.

Managing moderate to severe thalassaemia:
Some of the most general methods of managing and treating thalassaemia include:

Frequent blood transfusions: When the thalassaemia gets too severe, it becomes necessary to opt for blood transfusion after every few weeks. The blood transfusion can cause iron build up with the passage of time. This, in turn, can affect the heart and lungs along with other crucial organs. Therefore, it is important to take medicines that can eliminate the extra iron.
Stem cell transplant: Also referred to as the bone marrow transplant, the stem cell transplant can be the best bet. It is recommended for kids who are born with severe thalassaemia. This treatment option can mitigate the need of a lifelong transfusion of blood and intake of drugs for controlling the iron overload.
Thallasemia generally occurs in pockets like in Haryana, Punjab, Delhi, Uttar Pradesh, Chhattisgarh, etc. The concerned state units of these states need to take guidance from doctors for definite treatment which is bone marrow transplant.
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I am Harmanpreet Singh the patient of thalassemia major and need blood transfusion after every 15 days I just wanna know the cost of blood transfusion in canada or australia because I am planning to go canada for my higher studies. I am 18 years old. Please reply.

Ex Sen.V.Surgeon/Research Scientist, M.D.(Alternative Medicine/tibetan/chinese/acupuncture), Vaida/ Unani, Homeopath
Unani Specialist, Moga
I am Harmanpreet Singh the patient of thalassemia major and need blood transfusion after every 15 days I just wanna k...
Hi you r not fit for travel. In my opinion you take our medicine course ist -4 months and get cured, then go to other country.
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Thalassemia - Types, Causes And Symptoms!

Fellowship In Leukemia & Stem Cell Transplant, DM - Clinical Haematology, MD - Medicine
Hematologist, Nagpur
Thalassemia - Types, Causes And Symptoms!
Thalassemia is a genetic (i.e., passed from parents to children through genes) blood disorder. People with Thalassemia disease are not able to make enough hemoglobin, which causes severe anemia. Hemoglobin is found in red blood cells and carries oxygen to all parts of the body. When there is not enough hemoglobin in the red blood cells, oxygen cannot get to all parts of the body. Organs then become starved for oxygen and are unable to function properly.

There are two types of Thalassemia disease-

Alpha Thalassemia disease: There are two main types of Alpha Thalassemia disease. Alpha Thalassemia Major is a very serious disease in which severe anemia begins even before birth. Pregnant women carrying affected fetuses are themselves at risk for serious pregnancy and delivery complications. Another type of Alpha Thalassemia is Hemoglobin H disease. There are varying degrees of Hemoglobin H disease.
Beta Thalassemia disease: Beta Thalassemia Major (also called Cooley's Anemia) is a serious illness. Symptoms appear in the first two years of life and include paleness of the skin, poor appetite, irritability, and failure to grow. Proper treatment includes routine blood transfusions and other therapies.
Causes of Thalassemia-

Thalassemia occurs when there s an abnormality or mutation in one of the genes involved in hemoglobin production. You inherit this genetic defect from your parents.

If only one of the parents is a carrier for thalassemia, the child may develop a form of the disease known as thalassemia minor. If this occurs, the born child probably won t have symptoms, but he/she will be a carrier of the disease. Some people with thalassemia minor do develop minor symptoms.

If both of your parents are carriers of thalassemia, you have a greater chance of inheriting a more serious form of the disease.

Symptoms-

The symptoms depend on the type of thalassemia:

Thalassemia Minor: Thalassemia minor usually doesn t cause any symptoms. If it does, it causes minor anemia.
Beta-thalassemia: Beta-thalassemia comes in two serious types, which are thalassemia major, or Cooley s anemia, and thalassemia intermedia. The symptoms of thalassemia major generally appear before a child s second birthday. The severe anemia related to this condition can be life-threatening. Other signs and symptoms include:
fussiness
paleness
frequent infections
a poor appetite
failure to thrive
jaundice, which is a yellowing of the skin or the whites of the eyes
enlarged organs
This form of thalassemia is usually so severe that it requires regular blood transfusions.

Alpha-thalassemia: Alpha-thalassemia also has two serious types, which are hemoglobin H disease and hydrops fetalis. Hemoglobin H disease can cause bone issues. The cheeks, forehead, and jaw may all overgrow. Hemoglobin H disease can cause:
jaundice, which is a yellowing of the skin or the whites of the eyes
an extremely enlarged spleen
malnourishment
Hydrops fetalis is an extremely severe form of thalassemia. It occurs before birth. Most individuals with this condition are either stillborn or die shortly after being born.

How is thalassemia diagnosed?

Thalassaemia is often detected during pregnancy or soon after birth.

Screening during pregnancy: Screening to check if a baby is at risk of being born with thalassemia is offered to all pregnant women.
Testing after birth or later in life: Newborn babies aren't routinely tested for thalassemia because the test used isn't always reliable soon after birth and the condition isn't immediately dangerous. However, the main form of the condition beta thalassemia major is often picked up as part of the newborn blood spot test (heel prick). A blood test can be carried out at any point to diagnose the condition if a child or adult has symptoms of thalassemia and the condition wasn't picked up earlier on.
Testing for the Thalassemia Trait- A blood test can be done at any time to find out if you have the thalassemia trait and are at risk of having a child with the condition. This can be particularly useful if you have a family history of the condition or your partner is known to carry thalassemia.
If your child has thalassemia, blood tests may reveal:

A low level of red blood cells
Smaller than expected red blood cells
Pale red blood cells
Red blood cells that are varied in size and shape
Red blood cells with uneven hemoglobin distribution, which gives the cells a bull's-eye appearance under the microscope
Blood tests may also be used to:

Measure the amount of iron in your child's blood
Evaluate his or her hemoglobin
Perform DNA analysis to diagnose thalassemia or to determine if a person is carrying mutated hemoglobin genes
Treatment for Thalassemia-

The treatment for thalassemia depends on the type and severity of disease involved. Your doctor will give you a course of treatment that will work best for your particular case.

Some of the utilized treatments include:

blood transfusions
a bone marrow transplant (BMT)
medications and supplements
possible surgery to remove the spleen or gallbladder

Hello I am 25 years old and having thalassemia minor. So is there any issue or any affect after baby?

MBBS, MS - Obstetrics and Gynaecology
Gynaecologist, Ghaziabad
Hello I am 25 years old and having thalassemia minor. So is there any issue or any affect after baby?
If your partner is not Thalessemic minor then nothing to worry. But if he is also minor then some invasive test will be required in early preg.
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Neither I am nor my wife is having thalassemia. My 2.5 years old baby boy have 10.9 haemoglobin. Is there any possibility of having thalassemia. please advise.

DM - Clinical Haematology, MD - General Medicine, MBBS
Hematologist, Durgapur
Neither I am nor my wife is having thalassemia. My 2.5 years old baby boy have 10.9 haemoglobin. Is there any possibi...
Thalassemia can be diagnosed only by screening hb HPLC test. If your baby is having anemia, it is wise to go for thalassemia screening test. Thanks.
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My brother is a thalassemia major patient and his entire body is swollen .plz advise what needs to be done .he is 28 years.

BHMS
Homeopath, Hyderabad
My brother is a thalassemia major patient and his entire body is swollen .plz advise what needs to be done .he is 28 ...
He needs regular follow up and therefore please visit your doctor as suggested. You can also add Homeopathy which is safe and gentle and does not cause any side-effects. It improves the immune system and helps natural healing. It can be taken along with the regular medicines. You can contact me for a detailed consultation.
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Diagnosing Thalassemia - How Can It Be Done?

MBBS Bachelor of Medicine and Bachelor of Surgery, MD - Medicine, DM - Clinical Hematology
Hematologist, Patna
Diagnosing Thalassemia - How Can It Be Done?
Thalassemia is a genetic (i.e., passed from parents to children through genes) blood disorder. People with Thalassemia disease are not able to make enough hemoglobin, which causes severe anemia. Hemoglobin is found in red blood cells and carries oxygen to all parts of the body. When there is not enough hemoglobin in the red blood cells, oxygen cannot get to all parts of the body. Organs then become starved for oxygen and are unable to function properly.

There are two types of Thalassemia disease-

Alpha Thalassemia disease: There are two main types of Alpha Thalassemia disease. Alpha Thalassemia Major is a very serious disease in which severe anemia begins even before birth. Pregnant women carrying affected fetuses are themselves at risk for serious pregnancy and delivery complications. Another type of Alpha Thalassemia is Hemoglobin H disease. There are varying degrees of Hemoglobin H disease.
Beta Thalassemia disease: Beta Thalassemia Major (also called Cooley's Anemia) is a serious illness. Symptoms appear in the first two years of life and include paleness of the skin, poor appetite, irritability, and failure to grow. Proper treatment includes routine blood transfusions and other therapies.
Causes of Thalassemia-

Thalassemia occurs when there s an abnormality or mutation in one of the genes involved in hemoglobin production. You inherit this genetic defect from your parents.

If only one of the parents is a carrier for thalassemia, the child may develop a form of the disease known as thalassemia minor. If this occurs, the born child probably won t have symptoms, but he/she will be a carrier of the disease. Some people with thalassemia minor do develop minor symptoms.

If both of your parents are carriers of thalassemia, you have a greater chance of inheriting a more serious form of the disease.

Symptoms-

The symptoms depend on the type of thalassemia:

Thalassemia Minor: Thalassemia minor usually doesn t cause any symptoms. If it does, it causes minor anemia.
Beta-thalassemia: Beta-thalassemia comes in two serious types, which are thalassemia major, or Cooley s anemia, and thalassemia intermedia. The symptoms of thalassemia major generally appear before a child s second birthday. The severe anemia related to this condition can be life-threatening. Other signs and symptoms include:
fussiness
paleness
frequent infections
a poor appetite
failure to thrive
jaundice, which is a yellowing of the skin or the whites of the eyes
enlarged organs
This form of thalassemia is usually so severe that it requires regular blood transfusions.

Alpha-thalassemia: Alpha-thalassemia also has two serious types, which are hemoglobin H disease and hydrops fetalis. Hemoglobin H disease can cause bone issues. The cheeks, forehead, and jaw may all overgrow. Hemoglobin H disease can cause:
jaundice, which is a yellowing of the skin or the whites of the eyes
an extremely enlarged spleen
malnourishment
Hydrops fetalis is an extremely severe form of thalassemia. It occurs before birth. Most individuals with this condition are either stillborn or die shortly after being born.

How is thalassemia diagnosed?

Thalassaemia is often detected during pregnancy or soon after birth.

Screening during pregnancy: Screening to check if a baby is at risk of being born with thalassemia is offered to all pregnant women.
Testing after birth or later in life: Newborn babies aren't routinely tested for thalassemia because the test used isn't always reliable soon after birth and the condition isn't immediately dangerous. However, the main form of the condition beta thalassemia major is often picked up as part of the newborn blood spot test (heel prick). A blood test can be carried out at any point to diagnose the condition if a child or adult has symptoms of thalassemia and the condition wasn't picked up earlier on.
Testing for the Thalassemia Trait- A blood test can be done at any time to find out if you have the thalassemia trait and are at risk of having a child with the condition. This can be particularly useful if you have a family history of the condition or your partner is known to carry thalassemia.
If your child has thalassemia, blood tests may reveal:

A low level of red blood cells
Smaller than expected red blood cells
Pale red blood cells
Red blood cells that are varied in size and shape
Red blood cells with uneven hemoglobin distribution, which gives the cells a bull's-eye appearance under the microscope
Blood tests may also be used to:

Measure the amount of iron in your child's blood
Evaluate his or her hemoglobin
Perform DNA analysis to diagnose thalassemia or to determine if a person is carrying mutated hemoglobin genes
Treatment for Thalassemia-

The treatment for thalassemia depends on the type and severity of disease involved. Your doctor will give you a course of treatment that will work best for your particular case.

Some of the utilized treatments include:

blood transfusions
a bone marrow transplant (BMT)
medications and supplements
possible surgery to remove the spleen or gallbladder
2583 people found this helpful

My Partner 24 years old carry beta thalassemia minor, I am 32 years old I am normal, I want to know my child chance to thalassemia or not please suggest me.

Diploma In Gastroenterology, Diploma In Dermatology, BHMS
Homeopath, Hyderabad
My Partner 24 years old carry beta thalassemia minor, I am 32 years old I am normal, I want to know my child chance t...
Yes theres a 50 percent chance of having a thalassemia minor baby and 50 percent chance of having a normal child..
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