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HE4 with Roma Index (Epithelial Ovarian Cancer) Health Feed

What Is Ovarian Cancer?

Diploma In Gastroenterology, Diploma In Dermatology, BHMS
Homeopath, Hyderabad
What Is Ovarian Cancer?
The ovaries are mainly made up of 3 kinds of cells.... Most ovarian tumors are epithelial cell tumors. Germ cell tumors start from the cells that produce the eggs (ova). Stromal tumors start from structural tissue cells that hold the ovary together and produce the female hormones estrogen and progesterone.

Types:

The ovaries are made up of three types of cells. Each cell can develop into a different type of tumor:

-Epithelial tumors form in the layer of tissue on the outside of the ovaries. About 90 percent of ovarian cancers are epithelial tumors
-Stromal tumors grow in the hormone-producing cells. Seven percent of ovarian cancers are stromal tumors.
-Germ cell tumors develop in the egg-producing cells. Germ cell tumors are rare.

Causes:

Ovarian cancer happens when cells divide and multiply in an unregulated way. However, exactly why this happens is not clear.

The following risk factors are linked to a higher chance of developing the disease:

*Family history:
Women with close relatives who have had ovarian or breast cancer have a higher risk of developing ovarian cancer, compared with other women. Genetic screening can determine whether somebody carries certain genes that are associated with an increased risk.

*Age:
Most cases of ovarian cancer occur after menopause, and especially in women aged over 63 years. It is rare before the age of 40 years.

*Reproductive history:
Women who have had one or more full-term pregnancies, especially before the age of 26 years, have a lower risk. The more pregnancies they have, the lower the risk.

*Breastfeeding may also decrease the risk.

-Birth control:
Using the contraceptive pill for at least 3 to 6 months appears to reduce the risk. The longer the pill is used, the lower the risk appears to be. Using an injectible contraceptive hormone, depot medroxyprogesterone acetate (DMPA or Depo-Provera CI), especially for 3 years or more, reduces the risk further.

-Infertility or fertility treatment:
Fertility drugs have been linked to a higher risk of ovarian cancer, especially in women who used them for more than one year without becoming pregnant. Those who are infertile may also have a higher risk than those who are not, possible due to not carrying a pregnancy.

-Breast cancer:
Women who have received a diagnosis of breast cancer have a higher chance of being diagnosed with ovarian cancer.

For this reason, women who are diagnosed with breast cancer and who test positive for the BRCA1 or BRCA2 gene may opt to have an oophorectomy as preventive therapy.

Symptoms:

It s easy to overlook the early symptoms of ovarian cancer because they re similar to other common illnesses or they tend to come and go. The early symptoms include:

-abdominal bloating, pressure, and pain
-abnormal fullness after eating
-difficulty eating
-an increase in urination
-an increased urge to urinate

*Ovarian cancer can also cause other symptoms, such as:

-fatigue
-indigestion
-heartburn
-constipation
-back pain
-menstrual irregularities
-painful intercourse
-dermatomyositis (a rare inflammatory disease that can cause skin rash, muscle weakness, and inflamed muscles)

These symptoms may occur for any number of reasons. They aren t necessarily due to ovarian cancer. Many women have some of these problems at one time or another. These types of symptoms are often temporary and respond to simple treatments in most cases.

Again, cancers are best treated when detected early. Please consult with your doctor if you experience new and unusual symptoms.

The symptoms will persist if they re due to ovarian cancer. Symptoms usually become more severe as the tumor grows. By this time, the cancer has usually spread outside of the ovaries, making it much harder to treat effectively.

Diagnosis:

A doctor will carry out a pelvic examination and check for any palpable abnormalities in the uterus or ovaries. They will also check the patient's medical history and family history.

The following tests are used to help diagnose ovarian cancer:

-Blood tests: Checking for elevated levels of a marker called CA-125.

-Imaging tests: Transvaginal ultrasound, MRI, or a CT scan might be used.

-Laparoscopy: A laparoscope, a thin viewing tube with a camera at the end, is inserted through a small incision in the lower abdomen. This will allow the doctor to see the ovaries and, if necessary, to take a tissue sample

-Colonoscopy: If there is constipation or bleeding from the rectum, a colonoscopy may be needed, to examine the large intestine, or colon.

-Abdominal fluid aspiration: If the patient's abdomen is swollen, there may be a buildup of fluid, which can be examined by using a fine needle to remove some fluid through the abdomen.

-Biopsy: The usual way to diagnose ovarian cancer is to remove the tumor or part of the tumor to examine for the presence of cancer cells.

Role of Homeopathy In Ovarian:

Treatment of ovarian cancer has to be multi-way therapy. Its not either Homeopathy or conventional treatment. The best long-term results are achieved by combination therapy depending on age, stage of ovarian cancer and general health condition of patient. While conventional treatments like chemotherapy or radiation therapy helps in faster removal of cancer, Homeopathy Treatment for ovarian cancer can help in:

-Regression of ovarian cancer
-Prevention of recurrence of ovarian cancer,
-Removing side-effects of chemo and radiation therapy,
-Relieving cancer pains
-Improving general quality of life and hence, a better reaction to other treatments.

The speciality Homeopathic treatment for ovarian cancer, developed at Welling Clinics can be very helpful for those suffering from ovarian cancer.

Diet and non-diet:

There is no proven evidence regarding the cause of PCOD though gynaecologists are of the opinion that some females possess a predisposition to this disease, and it may run hereditarily in the family. You can alleviate your PCOD symptoms to a considerable extent by regulating your diet properly.

Have loads of fruits and green leafy vegetables and try to abstain from dairy products as many experts believe that dairy products are a direct cause of an increase in insulin levels, which can aggravate skin troubles along with other PCOD symptoms. Avoiding red meat and eating lean meat instead will help the condition and reduce the chances of infertility. It is always recommended to avoid hydrogenated and saturated fats, which are normally found in animal and dairy-based food. Try to put a stop to cheese, cottage cheese, clarified butter, pork, lamb, beef, etc. and certain baked products like cookies, cakes and fudges as they will trigger a rise in your blood sugar and cholesterol levels.
2979 people found this helpful

Ovarian Cancer - Symptoms & Ways To Treat It!

DM - Oncology, MD - Internal Medicine
Oncologist, Bhubaneswar
Ovarian Cancer - Symptoms & Ways To Treat It!
Amongst the different types of gynecological cancers prevalent today, ovarian cancer is associated with the highest rate of fatality. This type of cancer refers to tumours that grow in the ovaries. In most cases, these develop on the outer lining or epithelium of the ovary. Though this type of cancer is difficult to treat in its later stages, if diagnosed early enough it can be easily managed.

In the early stages of ovarian cancer, very few symptoms may be present. Many women do not experience any symptoms at all. The symptoms that may be experienced can be associated with other conditions and hence often go unrecognized. However, in the case of ovarian cancer, these symptoms will gradually increase and worsen with time. Some of the early symptoms of ovarian cancer could include:

Pain in the lower stomach or pelvic area
Back aches
Indigestion
Frequent urge to urinate
Painful intercourse
Change in bowel habits
Nausea
Weight loss
Fatigue
Loss of appetite or feeling full without eating too much
Ovarian cancer usually affects women over the age of 65. Women with a family history of breast cancer or ovarian cancer have a higher risk of developing these tumours. Endometriosis and hormone replacement therapy could also increase one s risk of ovarian cancer.

As with other types of cancer, treatment for ovarian cancer depends largely on how far it has advanced. The main forms of treatment include surgery, chemotherapy and radiation. Surgery is usually the first step of treating ovarian cancer. This involves a partial or complete hysterectomy. In the former, only one ovary and the adjoining fallopian tube is removed while in the latter both ovaries, fallopian tubes and the uterus are removed. The lymph nodes around the reproductive system and the fatty tissue in the abdomen may also be removed. A woman can conceive a child after a partial hysterectomy. In cases of advanced ovarian cancer, surgery may also include removing cancerous cells from the urinary system, intestines and spleen.

Surgery is usually followed by chemotherapy, medication for targeted therapy or hormone therapy. Radiation is rarely used to treat ovarian cancer. In addition, many patients also require counselling to cope with body change issues and the loss of sexual desire. Ovarian cancer can recur and hence it is also important to get regularly screened for any signs of recurrent tumours. In cases of recurrent cancer, chemotherapy is the most preferred form of treatment.
3142 people found this helpful

Ovarian Cysts - Knowing The Causes & Symptoms Of It!

DGO, DNB - Obs & Gynae, Certificate Training In Gynaecologic Endoscopy, MBBS Bachelor of Medicine and Bachelor of Surgery
Gynaecologist, Mumbai
Ovarian Cysts - Knowing The Causes & Symptoms Of It!
The ovaries are the egg producing organs, an essential part of the female reproductive system, they are responsible for the production of estrogen and release an egg every month. If the egg is fertilized with a sperm it can result in a pregnancy.

Ovarian cysts are quite common among women. Ovarian cysts are known to be small sacs filled with fluid that are situated in the ovaries.

Causes of ovarian cysts: Among ovarian cysts, the most common one is called the 'functional cyst'. This type of cyst is generally formed during the process of ovulation, wherein either the eggs do not successfully release from the sac or the sac (follicle) fails to disintegrate properly after the release of the egg.

Certain factors that can cause ovarian cysts are:

Age that is ovarian cysts are more likely to occur in women who have reached menopause
Smoking
Being overweight or obese
Consumption of fertility drugs
Hormone replacement therapy
Family history of ovarian cysts and cancer
Early menstruation, that is, the onset of the period before the age of 11
Hypothyroidism
Symptoms related to ovarian cysts: Generally, ovarian cysts show no specific symptoms and are generally located during a physical examination or an ultrasound. But, in case you suffer from large cysts or those that have ruptured, you may experience certain signs like:

Pain while having sex. Great discomfort may be felt, particularly when deep penetration is attempted.
Pain in the lower abdominal and pelvic region. This pain may be intermittent or persistent. It can also vary from being mild to quite sharp.
Irregularity in the menstrual cycle.
An uncomfortable pressure in the lower abdominal and pelvic area.
Acute pain in the pelvic area and the lower back all throughout the menstrual period.
Pain in the pelvic area after a session of vigorous exercise or strenuous physical activity.
A feeling of discomfort or pain while urinating or during bowel movements.
Nausea, followed by vomiting.
Pain in the vaginal area, or light bleeding.
Infertility
Problems with healthy bowel movements.
Bloating
4314 people found this helpful

Gynecological Cancer - Know The Signs And Symptoms!

MBBS Bachelor of Medicine and Bachelor of Surgery, MD - Obstetrics & Gynaecology
Gynaecologist, Delhi
Gynecological Cancer - Know The Signs And Symptoms!
Being diagnosed with cancer is something no one looks forward to and Gynaecological Cancer is every woman s worst nightmare. However, if diagnosed in time, it can be treated. Cancer in any part of a woman s reproductive system is termed as gynecological cancer. It is of five types:

Cervical cancer

Ovarian cancer

Vaginal cancer

Vulvar cancer and

Uterine cancer

Paying attention to your body and understanding its natural rhythm can help you recognize signs of gynecological cancer. This is because signs of gynecological cancer can be difficult to identify unless you know your body. Here are a five signs to watch out for-

Abnormal Vaginal Bleeding: Bleeding in between periods is okay once in a while but if it happens continuously over a period of 2 to 3 months, do not ignore it. Vaginal bleeding after menopause should also never be ignored. Abnormal bleeding could be triggered by a number of conditions including cancer of the lining of the uterus. Sudden changes in your menstrual blood that persist for over 2 cycles such as heavy bleeding can also be a symptom of uterine cancer. Heavy bleeding can be defined as a period that lasts for over 7 days.

Changes in the Vulva: Any change in colour of development of bumps, sores of thickened skin should be immediately shown to a gynecologist. Any form of vulvar itching or burning should also not be ignored. These conditions could be symptoms of vulvar cancer. Hence, it is important to know what your vulva looks like normally.

Bloating: Persistent bloating that lasts for over a fortnight can be a sign of ovarian cancer. This is especially true in cases of bloating accompanied by sudden weight loss or between-period bleeding.

Change in Bathroom Habits: Due to the proximity of the bladder to the reproductive organs, a tumour or swelling in the reproductive organs can trigger symptoms similar to those of a urinary tract infection. This includes pain while urinating, difficulty passing urine, diarrhea or constipation. Urinary incontinence could also a sign of gynecological cancer.

Abdominal or Back Pain: In rare cases, lower back pain could be a sign of ovarian cancer or uterine cancer. Pain in the lower abdomen or pelvic area can also be a sign of ovarian cancer.

The above could also be signs of other health disorders. The only way of knowing for sure is by consulting a doctor. Hence, understand your body and if you notice any of these symptoms consult your gynecologist at the earliest.
3691 people found this helpful

Ovarian Cancer - All You Should Be Knowing About It!

European Society For Medical Oncology certification, DM - Oncology, MD - General Medicine, MBBS, Fellowship in Bone Marrow Transplant
Oncologist, Faridabad
Ovarian Cancer - All You Should Be Knowing About It!
Ovarian cancer is referred to as the cancer of the ovaries. The ovaries are a component of the female reproductive system. There are two ovaries located on either side of the uterus in a woman's body. Ovaries which are the organs responsible for producing egg cells also produce the hormones estrogen and progesterone.

Ovarian cancer is a type of cancer which often goes undetected until it has spread all the way to the pelvis and the abdomen. However, it is also very difficult to treat the condition in its later stages which is why diagnosing ovarian cancer quickly is quintessential. Here is everything you need to know about ovarian cancer;

Symptoms:

No symptoms at first: Usually, in its early stages ovarian cancer does not cause any symptoms.
Abnormal bloating: Bloating is when your abdomen swells due to excess fluid or gas inside. Abnormal bloating is more frequently associated with irritable bowel syndrome or even constipation is a common symptom of ovarian cancer.
Feeling full quickly: This is also an associated symptom which has often been mistaken for constipation or irritable bowel syndrome.
Weight loss: This is one of the more common signs of ovarian cancer.
Discomfort in the pelvis area: This symptom occurs towards the later stages of ovarian cancer after it has already spread.
Constipation: Constipation is a symptom of ovarian cancer as well.
Frequent urination: This is yet another symptom which is a sign of ovarian cancer.
The symptoms of ovarian cancer are often mistaken with that of irritable bowel syndrome and constipation.

Causes: As with other forms of cancer, it is still very unclear what exactly causes ovarian cancer.

Treatment:

Surgery: Surgery most commonly involves removing large parts of the female reproductive system which includes the ovaries, the fallopian tubes, the uterus as well as the lymph nodes. The surgeon will also try and remove as many cancer cells as possible from the abdomen and pelvic areas.
Chemotherapy: Chemotherapy is usually done after surgery. It is usually performed so that the rest of the cancer cells are killed off. Chemotherapy drugs can be injected directly into the vein, abdominal cavity or sometimes even both.
3209 people found this helpful

Ovarian Cancer - Knowing The Early Signs & Symptoms Of It!

MBBS, MS - Oncology, DNB ( General Surgery )
Oncologist, Bangalore
Ovarian Cancer - Knowing The Early Signs & Symptoms Of It!
Ovarian cancer tends to occur in the cells of an ovary. The ovaries are the two glands which are responsible for female reproduction. They produce ova or eggs and also create the female hormones oestrogen and progesterone. Ovarian cancer begins when abnormal cells in the ovary start to multiply rapidly and grow out of control to form a tumour.

Generally, it was believed that ovarian cancer does not deliver any specific side effects until the tumour has spread to a later stage and early indications of ovarian cancer were not recognizable.

Nonetheless, in some of the cases, ovarian cancer may bring about early indications. The most widely recognized symptoms of ovarian cancer are as follows:

Constant bloating
Ache in your gut or pelvis
Inconvenience eating
Feeling full instantly
Urinary issues, for example, an urgent need to urinate or urinating more frequently than expected
In case that you have at least one of these side effects and it happens every day for more than two or three weeks, try to consult a doctor or a specialist.

These symptoms are basic for a few women. They may not imply that you have ovarian cancer. It is very important for women to understand that these symptoms do not necessarily imply that they have ovarian cancer. The same number of other common and harmless conditions can bring about the same indications. Additionally, different reasons for these symptoms are significantly more common than ovarian cancer. These may include irritable bowel syndromeand urinary tract infections (UTIs). In any case, the early indications of ovarian cancer tend to follow a pattern, which is as follows:

They begin abruptly.

They do not feel the same as your typical stomach-related or menstrual issues.

They happen almost consistently and do not leave.

Different signs and symptoms that affect a few women with ovarian cancer include the following:

Digestion problem

Fatigue

Back pain.

Pain during intercourse

Constipation

Menstrual cycle changes

However, these side effects are also common in a few women who do not have ovarian cancer. Most of the ovarian cancer cases are diagnosed at a later stage after the tumours have spread. Fortunately, around 20% of women are diagnosed early, when the infection might be generally treatable. There is no complete screening test for early ovarian cancer. General pelvic examinations now and then, followed by ultrasound examinations or blood tests for cancer-related markers, have been routinely used for ovarian cancer screening. However, none of these tests are particularly effective when it comes to identifying ovarian cancer.

In case some of these symptoms start to manifest in your body, one should go for a general check-up. This is so because cancers are usually diagnosed at later stages where treatment is very difficult. Hence, the sooner one knows, the better it is.
3355 people found this helpful

Ovarian Cysts - Causes & Symptoms Of The Condition!

MBBS Bachelor of Medicine and Bachelor of Surgery, MS
Gynaecologist, Faridabad
Ovarian Cysts - Causes & Symptoms Of The Condition!
The ovaries are the egg producing organs, an essential part of the female reproductive system, they are responsible for the production of estrogen and release and egg every month. If the egg fertilizes with a sperm it can result in a pregnancy.


Ovarian cysts are quite common among women. Ovarian cysts are known to be small sacs filled with fluid that are situated in the ovaries.
Causes of ovarian cysts


Among ovarian cysts, the most common one is called the functional cyst. This type of cyst generally forms during the process of ovulation, during which either the eggs do not successfully release from the sac or the sac (follicle) fails to disintegrate properly after the release of the egg. Certain factors that can cause ovarian cysts are-


1. Age- Ovarian cysts are more likely to occur in women who have reached menopause.
2. Smoking
3. Being overweight or obese
4. Consumption of fertility drugs
5. Hormone replacement therapy
6. Family history of ovarian cysts and cancer
7. Early menstruation, that is, the onset of the period before the age of 11
8. Hypothyroidism


Symptoms related to ovarian cysts
Generally, ovarian cysts show no specific symptoms and are generally only located during a physical examination or an ultrasound. But, in case you suffer from large cysts or those that have ruptured, you may experience certain signs like-


1. Pain while having sex. Great discomfort may be felt, particularly when deep penetration is attempted.
2. Pain in the lower abdominal and pelvic region. This pain may be intermittent or persistent. It can also vary from being mild to quite sharp.
3. Irregularity in the menstrual cycle.
4. An uncomfortable pressure in the lower abdominal and pelvic area.
5. Acute pain in the pelvic area and the lower back all throughout the menstrual period.
6. Pain in the pelvic area after a session of vigorous exercise or strenuous physical activity.
7. A feeling of discomfort or pain while urinating or during bowel movements.
8. Nausea, followed by vomiting.
9. Pain in the vaginal area, or light bleeding
10. Infertility
11. Problems with healthy bowel movements
12. Bloating
3311 people found this helpful

Ovarian Cancer - Symptoms You Should Never Ignore!

Multi Speciality, Navi Mumbai
Ovarian Cancer - Symptoms You Should Never Ignore!
Ovarian cancer is a broad term used to describe cluster of different types of cancers occurring in a single organ i.e. ovary. It can occur at any age- from infancy till old age , even though ovarian carcinoma in younger/childhood comprises only 20% of all ovarian cancers. Majority of ovarian cancers are epithelial - arising from the covering from ovary or from the fallopian tube or the lining of the peritoneum of the abdominal cavity.

The Silent Killer:

Ovarian cancer is called a silent killer as majority of patients report any symptoms when the disease is in the advance stage. Hardly 2-3% of all ovarian cancers cause bleeding or hirsutism, thereby seeking prompt treatment. Majority of ovarian cancer occurs in peri/postmenopausal women which reflect change in interior milieu in terms of hormones.

Since the symptoms are non-specific, women tend to ignore them due to growing age/menopause. Also, mostly women normally don't consult physicians for such non-gynecological complaints, thereby further delaying the diagnosis. It is recommended that women remain involved in their overall health and keep themselves updated to report any abnormality immediately to a specialist.

The main symptoms associated with Ovarian Cancer are:

Bloating sensation especially after heavy meals.

Increasing abdominal girth (especially if no change in diet or if regularly exercising).

Increasing heaviness (fullness) in lower abdomen.

Increasing constipation.

Persistent Gastritis, if previously absent.

Inability to eat proper meal.

Increasing tiredness.

Increased frequency of urination.

Painful contact.

Further, if there is family history of breast/uterine/ovarian cancer in first and second degree relatives, this increases the risk of developing ovarian and breast cancer. Such females should remain vigilant for above-mentioned symptoms and should report promptly.
4793 people found this helpful

Ovarian Cysts - Understanding The Causes & Symptoms Of It!

MS - Obstetrics and Gynaecology
Gynaecologist, Ahmedabad
Ovarian Cysts - Understanding The Causes & Symptoms Of It!
The ovaries are the egg producing organs, an essential part of the female reproductive system, they are responsible for the production of estrogen and release an egg every month. If the egg is fertilized with a sperm it can result in a pregnancy.

Ovarian cysts are quite common among women. Ovarian cysts are known to be small sacs filled with fluid that are situated in the ovaries.

Causes of ovarian cysts: Among ovarian cysts, the most common one is called the 'functional cyst'. This type of cyst is generally formed during the process of ovulation, wherein either the eggs do not successfully release from the sac or the sac (follicle) fails to disintegrate properly after the release of the egg.

Certain factors that can cause ovarian cysts are:

Age that is ovarian cysts are more likely to occur in women who have reached menopause
Smoking
Being overweight or obese
Consumption of fertility drugs
Hormone replacement therapy
Family history of ovarian cysts and cancer
Early menstruation, that is, the onset of the period before the age of 11
Hypothyroidism
Symptoms related to ovarian cysts: Generally, ovarian cysts show no specific symptoms and are generally located during a physical examination or an ultrasound. But, in case you suffer from large cysts or those that have ruptured, you may experience certain signs like:

Pain while having sex. Great discomfort may be felt, particularly when deep penetration is attempted.
Pain in the lower abdominal and pelvic region. This pain may be intermittent or persistent. It can also vary from being mild to quite sharp.
Irregularity in the menstrual cycle.
An uncomfortable pressure in the lower abdominal and pelvic area.
Acute pain in the pelvic area and the lower back all throughout the menstrual period.
Pain in the pelvic area after a session of vigorous exercise or strenuous physical activity.
A feeling of discomfort or pain while urinating or during bowel movements.
Nausea, followed by vomiting.
Pain in the vaginal area, or light bleeding.
Infertility
Problems with healthy bowel movements.
Bloating
3952 people found this helpful

Ovarian Cancer - What The News Medication Trends?

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Ovarian Cancer - What The News Medication Trends?
When a mutation occurs in the gametes or germ cells which later becomes sex cells, the mutation is referred to as germline mutation. The germline mutation, in the majority of cases, causes harmful genetic disorders or diseases like ovarian cancer that may have a potential of being passed on to offspring.

Considered to be one of the most lethal forms of all the gynecological malignancies that are there, ovarian cancer is a serious threat that can make people succumb to death. However, with modern genetic drugs being discovered, such as rucaparib and olaparib, treating BRCA germline as well as somatic ovarian cancer has been possible to a great extent. Let s take a closer look at these anti-cancer drugs here.

What are these drugs used for?
The drug rucaparib is used for treating patients who have had two or more sessions of chemotherapy for adverse somatic or germline BRCA mutation which is associated with ovarian cancer. On the other hand, the drug olaparib is used for patients who are suspected or have cancer due to germline BRCA mutation and have been treated with 3 or more chemotherapies before. These are both indicated as monotherapy.

Are there any side effects?
Patients taking rucaparib or olaparib are not meant to feel side effects. However, based on the duration of the treatment and the severity of the condition sometimes people may experience side effects like constipation, nausea, fatigue, kidney issues, decreased appetite, anemia, etc. The chances of experiencing skin rash, breathlessness, photosensitivity, heartburn and decreased the count of platelets are very less.

Are there any necessary precautions?
Before starting treatments with olaparib or rucaparib, patients are strongly suggested to tell their doctors about other medications they are taking presently, in case there's any. And, also, patients are advised against taking any vaccination or immunization or drugs containing aspirin without consulting their doctors. Both breastfeeding a child and conceiving during the treatment are strongly prohibited.

How do these drugs work?
Just like many other targeted therapies that are there for treating cancer, both rucaparib and olaparib primarily work by killing the malignant or the fast-dividing cells associated with ovarian cancer. However, finding out more about the other features of the cancer cells is also its purpose. The PARP enzymes these two drugs include, induce the formation of the double-stranded DNA complexes which results in the death of the cancer cells.
People having either BRCA1 or BRCA2 germline mutations stands at greater risk of developing certain cancers, such as ovarian cancer or the breast cancer than other people. However, research has shown promising chances of targeted therapies such as the rucaparib or olaparib to play an effective role in treating germline mutations caused cancers. You can always talk to your healthcare professional to know more about these targeted therapies if at risk.
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