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Congenital Nephrotic Syndrome - Know Signs Of It In Children!

Congenital Nephrotic Syndrome - Know Signs Of It In Children!
As the name suggests, congenital nephrotic syndrome affects the kidneys of newborn babies. Though congenital means the disease must be present from birth, babies who develop nephrotic syndrome in the first three months are also said to suffer from this condition. This is a rare genetic disorder that is passed down from parents to their children. Boys are at a higher risk of suffering from this disorder than girls. The congenital nephrotic syndrome causes the kidneys to leak large amounts of protein into the baby s urine. This can lead to swelling of the body tissues and a weakened immune system.

Some of the common symptoms of this disease include

Low birth weight
Lack of appetite
Swelling of the body
Foamy or frothy urine
Lowered urine production
Cough
Pregnant women are usually screened for this condition before the baby is born. The doctor will be looking for a placenta that is larger than normal in ultrasound and high levels of alpha fetoprotein in amniotic fluid samples. If found; the doctor might ask for a genetic test to confirm the diagnosis.

Once the baby is born, he or she will show signs of fluid retention as the body begins to swell. Other signs your doctor will look out for are high blood pressure, signs of malnutrition and abnormal sounds from the heart and lungs. A urine analysis will also show high levels of protein in the urine through the overall protein levels in the body may be low. The doctor may also ask for a kidney biopsy in some cases to confirm the diagnosis.

Aggressive forms of treatment in the early stages of this disease can help control it. This may include antibiotics, blood pressure medication, ACE inhibitors and angiotensin receptor blockers to reduce protein leakage and diuretics to manage excess fluid build-up. Nonsteroidal anti-inflammatory drugs may also help reduce the amount of protein leaking into the urine. In addition, the doctor may advise you to limit fluid the baby s fluid intake to control the swelling. As a last resort, the kidneys may need to be removed to prevent protein loss. This will be followed by dialysis or a kidney transplant.

If left unchecked, this disorder can lead to a number of complications including acute kidney failure, blood clots, infections and diseases related to malnutrition. It can also lead to the death of a baby in the first year of catching the infection or before his or her fifth birthday.
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Know More About The Causes, Signs And Treatment Of Cushing 's Syndrome!

Know More About The Causes, Signs And Treatment Of Cushing 's Syndrome!
The adrenal glands are present above the kidneys (hence the name) and produce an important hormone known as cortisol. Cortisol is responsible for regulating multiple body functions, including controlling blood pressure, protein and carbohydrate metabolism, and anti-inflammatory response, and stress management.

Under natural circumstances, the body produces excessive cortisol in the following situations:
Physically stressing situations like illness, surgery, injury, pregnancy, etc.

Emotionally stressed situations
Alcoholism
Athletic training
Malnutrition
Depression
Panic disorders
Causes: Cushing s syndrome is a group of symptoms that manifest when there is too much cortisol in the body. It is more common in women than men, in the age group of 25 to 40. Some of the common causes of Cushing s syndrome are listed below:

Consuming too much of prednisone (and other steroids) or for prolonged periods can cause Cushing s syndrome. These are strong anti-inflammatory medications and are used in asthma, arthritis, lupus, transplants, etc., to control the body s inflammation reaction. It is therefore advisable to use topical steroids than oral steroids or injections as their effects are more noticeable and severe.
Adrenal gland tumors can cause excessive production of cortisol.
Pituitary gland tumors or adenomas also can also cause excessive production of cortisol, leading to Cushing s syndrome.
The first type is known as exogenous Cushing s disease and the others are known as endogenous Cushing s disease.
Signs and symptoms: Cushing s disease produces characteristic features which are referred to as the Cushingoid appearance. These features include the following:

A rounded, plump face with a pinkish hue
A moon face, with fat deposits on the face
A buffalo hump with fat deposits between the shoulders
Stretch marks on the abdomen, thighs, and arms
Weak muscles, especially in the hips and shoulder
Significant weight gain
Skin that gets thin and bruises easily
Extreme tiredness
High blood pressure
High blood sugar
Thin arms and legs
Delayed healing of cuts and injuries
Increased facial hair in women
Menstrual disorders
Reduced libido, infertility, and erectile dysfunction in men
Emotional issues like depression, anxiety, irritability
Increased thirst and urination
Bone loss, and eventually fractures
Affected bone growth in the developing years
Increased susceptibility to infections
Complications: Untreated Cushing s disease can lead to bone fractures, hypertension, full-blown infections, kidney stones, etc.

Treatment: This would depend on the cause. If you are on long-term steroids, the dose would need to be adjusted. This should always be done under medical supervision, as it requires constant adjustment. Underlying tumors (pituitary or adrenal) need to be diagnosed and treated. There are other hormones too which come into the picture and need to be monitored.
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Nephrotic Syndrome - How To Get Rid Of It?

Nephrotic Syndrome - How To Get Rid Of It?
Nephrotic syndrome is a type of kidney disorder wherein, the body passes out excess amount of proteins through urine, owing to the damage caused to the tiny clusters of blood vessels in the kidneys. The symptoms include putting on excessive weight as a result of fluid retention, foamy urine and severe swelling around the region of the feet, ankles and eyes.

Common causes behind it

Minimal change disease (also known as nil disease) leads to the abnormal functioning of the kidneys
Excess deposit of amyloid proteins in the organs, thus taking a toll on the filter mechanism of the kidneys.
Diabetes affecting the glomeruli (capillaries present in the nephrons of the kidneys).
Systemic lupus erythematous causing chronic swelling of your kidney.
Membranous nephropathy wherein the membranes in your glomeruli thicken.
Infections such as malaria, hepatitis C, hepatitis B and HIV.
Medications to combat infections and nonsteroidal anti-inflammatory drugs.
Treatment Available

Kidney Biopsy is an essential part of disease assessment.
Angiotensin-converting enzyme inhibitors bring down blood pressure levels as well as the amount of protein discharged from the urine.
Water pills help control sweating, thus, increasing the fluid flushed from the kidneys.
Statins reduce cholesterol level.
Blood thinners such as anticoagulants lower the risk of blood clots.
Corticosteroids regulate the immune system and ease the inflammation that results from kidney disorders.
Incorporating certain lifestyle changes such as opting for lean proteins, cutting on the intake of fat in the diet and consuming lesser amounts of salt can treat inflammation and swelling.
3640 people found this helpful

Nephrotic Syndrome - Know Options Of Treatment!

Nephrotic Syndrome - Know Options Of Treatment!
Nephrotic syndrome is a type of kidney disorder wherein, the body passes out excess amount of proteins through urine, owing to the damage caused to the tiny clusters of blood vessels in the kidneys. The symptoms include putting on excessive weight as a result of fluid retention, foamy urine and severe swelling around the region of the feet, ankles and eyes.

Common causes behind it

Minimal change disease (also known as nil disease) leads to the abnormal functioning of the kidneys
Excess deposit of amyloid proteins in the organs, thus taking a toll on the filter mechanism of the kidneys.
Diabetes affecting the glomeruli (capillaries present in the nephrons of the kidneys).
Systemic lupus erythematous causing chronic swelling of your kidney.
Membranous nephropathy wherein the membranes in your glomeruli thicken.
Infections such as malaria, hepatitis C, hepatitis B and HIV.
Medications to combat infections and nonsteroidal anti-inflammatory drugs.
Treatment Available

Kidney Biopsy is an essential part of disease assessment.
Angiotensin-converting enzyme inhibitors bring down blood pressure levels as well as the amount of protein discharged from the urine.
Water pills help control sweating, thus, increasing the fluid flushed from the kidneys.
Statins reduce cholesterol level.
Blood thinners such as anticoagulants lower the risk of blood clots.
Corticosteroids regulate the immune system and ease the inflammation that results from kidney disorders.
Incorporating certain lifestyle changes such as opting for lean proteins, cutting on the intake of fat in the diet and consuming lesser amounts of salt can treat inflammation and swelling.
3870 people found this helpful

Cushing's Syndrome - Know Reasons Behind It!

Cushing's Syndrome  - Know Reasons Behind It!
Cushing s syndrome occurs due to abnormally high levels of the hormone cortisol. This can happen for a variety of reasons. The most common cause is overuse of corticosteroid medications.

Causes:

Your adrenal glands produce cortisol. It helps with a number of your body s functions, including:

regulating blood pressure and the cardiovascular system

reducing the immune system s inflammatory response

converting carbohydrates, fats, and proteins into energy

balancing the effects of insulin

responding to stress

Your body may produce high levels of cortisol for a variety of reasons, including:

high-stress levels, including stress related to an acute illness, surgery, injury, or pregnancy, especially in the final trimester

athletic training

malnutrition

alcoholism

depression, panic disorders, or high levels of emotional stress

The most common cause of Cushing s syndrome is the use of corticosteroid medications, such as prednisone, in high doses for a long period. High doses of injectable steroids for treatment of back pain can also cause this syndrome.

Other causes include:

a pituitary gland tumor in which the pituitary gland releases too much adrenocorticotropic hormone, which is also known as Cushing s disease

ectopic ACTH syndrome, which causes tumors that usually occur in the lung, pancreas, thyroid, or thymus gland

an adrenal gland abnormality or tumor

Symptoms of Cushing s Syndrome:

The most common symptoms of this condition are:

weight gain
obesity
fatty deposits, especially in the midsection, the face and between the shoulders and the upper back (causing a buffalo hump)
purple stretch marks on the breasts, arms, abdomen, and thighs
thinning skin that bruises easily
skin injuries that are slow to heal
acne
fatigue
muscle weakness
increased thirst
increased urination
bone loss
depression
an increased incidence of infections
Women may also notice extra facial and body hair, as well as absent or irregular menstruation.

Men may also have:

erectile dysfunction
a loss of sexual interest
decreased fertility
Children with this condition are generally obese and have a slower rate of growth.
2791 people found this helpful

Causes And Treatment Of Cushing's Syndrome!

Causes And Treatment Of Cushing's Syndrome!
The adrenal glands are present above the kidneys (hence the name) and produces an important hormone known as cortisol. Cortisol is responsible for regulating multiple body functions, including controlling the blood pressure, protein and carbohydrate metabolism, and anti-inflammatory response, and stress management.

Under natural circumstances, the body produces excessive cortisol in the following situations:
Physically stressing situations like illness, surgery, injury, pregnancy, etc.

Emotionally stressed situations
Alcoholism
Athletic training
Malnutrition
Depression
Panic disorders
Causes: Cushing s syndrome is a group of symptoms that manifest when there is too much cortisol in the body. It is more common in women than men, in the age group of 25 to 40. Some of the common causes for Cushing s syndrome are listed below:

Consuming too much of prednisone (and other steroids) or for prolonged periods can cause Cushing s syndrome. These are strong anti-inflammatory medications and are used in asthma, arthritis, lupus, transplants, etc., to control the body s inflammation reaction. It is therefore advisable to use topical steroids than oral steroids or injections as their effects are more noticeable and severe.
Adrenal gland tumours can cause excessive production of cortisol.
Pituitary gland tumours or adenomas also can also cause excessive production of cortisol, leading to Cushing s syndrome.
The first type is known as exogenous Cushing s disease and the others are known as endogenous Cushing s disease.
Signs and symptoms: Cushing s disease produces characteristic features which are referred to as the Cushingoid appearance. These features include the following:

A rounded, plump face with a pinkish hue
A moon face, with fat deposits on the face
A buffalo hump with fat deposits between the shoulders
Stretch marks on the abdomen, thighs, and arms
Weak muscles, especially in the hips and shoulder
Significant weight gain
Skin that gets thin and bruises easily
Extreme tiredness
High blood pressure
High blood sugar
Thin arms and legs
Delayed healing of cuts and injuries
Increased facial hair in women
Menstrual disorders
Reduced libido, infertility, and erectile dysfunction in men
Emotional issues like depression, anxiety, irritability
Increased thirst and urination
Bone loss, and eventually fractures
Affected bone growth in the developing years
Increased susceptibility to infections
Complications: Untreated Cushing s disease can lead to bone fractures, hypertension, full-blown infections, kidney stones, etc.

Treatment: This would depend on the cause. If you are on long-term steroids, the dose would need to be adjusted. This should always be done under medical supervision, as it requires constant adjustment. Underlying tumours (pituitary or adrenal) need to be diagnosed and treated. There are other hormones too which come into the picture and need to be monitored.
3312 people found this helpful

What is the diet and food for nephrotic syndrome patients? Please reply I am too sad.

What is the diet and food for nephrotic syndrome patients? Please reply I am too sad.
It should be limited in salt. Better take proper homoeopathic treatment. It can be cured by it. Food and diet will not help much.
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Nephrotic Syndrome - Can Diet Help In It?

Nephrotic Syndrome - Can Diet Help In It?
Nephrotic Syndrome is a condition which is characterised by the loss of protein into the urine (called proteinuria) as a result of increased glomerular permeability and oedema. This results in low protein level in the blood. The low levels of protein in blood result in the drawing of fluids into soft tissues. A severe form hypoalbuminemia can cause scores of secondary diseases such as ascites (retention of fluid in the abdominal cavity), pleural effusion (build-up of fluids between the lungs and the chest), or high cholesterol. It can also result in retention of fluid in other parts of the body such as eyelids, lower extremities etc.

What can cause this?
Nephrotic syndrome is mainly caused by damage to the kidneys. This leads to an increase in the concentration of protein in the urine. In adults, it can be caused due to glomerulonephritis or damage to the glomerulus of the kidneys while in children it is likely caused by minimal change disease (kidney disease marked by the abnormal loss of protein through the urine).

The other common causes of nephritic syndromes are:

Genetic disorder
Immune disorder
Cancer
Infection
Use of specific drugs
Certain diseases such as diabetes mellitus, lupus
The incidence of this disease is seen more often in males than in females.
Diet that is recommended in Nephrotic Syndrome:
In patients diagnosed with Nephrotic syndrome, the intake of salt, fat and protein must be checked. There should be emphasis on the consumption of dietary fibres that are present in vegetables and fruits.
The intake of protein and fluid should also be monitored, but this solely depends on personal factors such as age, weight and condition of the patient. It is recommended to consult a renal dietician who can guide you appropriately.

Sodium/salt intake: The sodium or salt intake must be restricted as it leads to high blood pressure and results in fluid retention in the body, thus causing oedema (build-up of fluids within the body cavities and tissues) in the body. Avoid processed food as it contains a lot of salt.
Protein intake: Protein is an essential part of the diet as it helps in the general makeup of the body and development of muscles. The consumption of protein must be kept under check and it is the best to consult your dietician for this. Loss of protein in urine needs to be replaced by class 1 high quality proteins in nephrotic syndrome.
Limit fat and cholesterol intake: It is always good to curb on bad cholesterol as it is the reason behind several heart diseases. But, with patients diagnosed with Nephrotic Syndrome, it is highly recommended to avoid food rich in fats. This means staying away from unhealthy fatty meat or junk food.
Fluid intake: Fluid intake does not have to be necessarily reduced, but it is always good to consult your doctor for the same.
You are what you eat . Nephrotic syndrome can slowly progress to chronic kidney disease if the necessary steps are not taken to curb it in an early stage, and diet control is a major way to do so.
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Cushing Syndrome - How To Diagnose It?

Cushing Syndrome - How To Diagnose It?
Cushing syndrome or round face syndrome, as some like to call it, is a hormonal disorder that is relatively uncommon. It is all about the stress hormone called Cortisol and how it can throw off the body systems. Read on to know the causes and symptoms of this disorder. But first of all, let us know what exactly is the Cushing syndrome?

When an individual's body is exposed more to a particular hormone called Cortisol, he/she may develop a condition called as Cushing syndrome. This can lead to unusual and uncomfortable symptoms. However, this condition of hypercortisolism is completely curable and the patients can continue to lead a normal life. Cushing syndrome is more common in women than in men and occurs mostly between the age of 25 to 40.

Symptoms of cushing syndrome

Excessive weight gain and obesity
Fatty deposits that tend to accumulate in the midsection, face (causing moon facies) or between the shoulders and upper back causing a hump
Fatigue and muscle weakness
Thinning skin that is prone to bruises easily
Purple stretch marks on the arms, thighs, abdomen and breast
Cognitive dysfunction with increased anxiety, irritability and depression
Women can experience extra facial and body hair with irregular or absent periods
High blood pressure and high blood sugar levels
Low sex drive and erectile dysfunction
Weak bones and osteoporosis
Children with this ailment tend to obese and experience a slow growth rate
Causes of Cushing Syndrome
As mentioned above the major cause of Cushing syndrome is the high production of Cortisol. This hormone is produced by the adrenal gland that sits on top of your kidneys. The prime reasons for the over-production of Cortisol can be:

High-stress levels
Malnutrition
Alcoholism
Depression, panic disorder and high levels of emotional stress
Athletic training
Also, another prime cause of this syndrome is the use of corticosteroid medications, such as prednisone, in high doses for a long period. These prescriptions are often given for conditions of asthma, organ transplant, lupus and rheumatoid arthritis. A tumor in the pituitary gland that is located at the base of the brain or a tumor in the adrenal glands can also lead to excessive production of Cortisol, thereby leading to Cushing Syndrome.

Diagnosis and treatment
Diagnosis is done by your doctor to determine the cause of the excess production of the hormone. Tests can include:

Blood Test or imaging scans
Dexamethasone suppression test
24-hour urinary free cortisol test
Late-night salivary cortisol level
Treatment will vary with the actual cause of the disorder. Medications to decrease cortisol levels or block them can be given.
2800 people found this helpful

Cushing's Syndrome - How To Identify It?

Cushing's Syndrome - How To Identify It?
The adrenal glands are present above the kidneys (hence the name) and produces an important hormone known as cortisol. Cortisol is responsible for regulating multiple body functions, including controlling the blood pressure, protein and carbohydrate metabolism, and anti-inflammatory response, and stress management.

Under natural circumstances, the body produces excessive cortisol in the following situations:

Physically stressing situations like illness, surgery, injury, pregnancy, etc.

Emotionally stressed situations
Alcoholism
Athletic training
Malnutrition
Depression
Panic disorders
Causes: Cushing s syndrome is a group of symptoms that manifest when there is too much cortisol in the body. It is more common in women than men, in the age group of 25 to 40. Some of the common causes of Cushing s syndrome are listed below:

Consuming too much of prednisone (and other steroids) or for prolonged periods can cause Cushing s syndrome. These are strong anti-inflammatory medications and are used in asthma, arthritis, lupus, transplants, etc., to control the body s inflammation reaction. It is therefore advisable to use topical steroids than oral steroids or injections as their effects are more noticeable and severe.
Adrenal gland tumours can cause excessive production of cortisol.
Pituitary gland tumours or adenomas also can also cause excessive production of cortisol, leading to Cushing s syndrome.
The first type is known as exogenous Cushing s disease and the others are known as endogenous Cushing s disease.

Signs and symptoms: Cushing s disease produces characteristic features which are referred to as the Cushingoid appearance. These features include the following:

A rounded, plump face with a pinkish hue
A moon face, with fat deposits on the face
A buffalo hump with fat deposits between the shoulders
Stretch marks on the abdomen, thighs, and arms
Weak muscles, especially in the hips and shoulder
Significant weight gain
Skin that gets thin and bruises easily
Extreme tiredness
High blood pressure
High blood sugar
Thin arms and legs
Delayed healing of cuts and injuries
Increased facial hair in women
Menstrual disorders
Reduced libido, infertility, and erectile dysfunction in men
Emotional issues like depression, anxiety, irritability
Increased thirst and urination
Bone loss, and eventually fractures
Affected bone growth in the developing years
Increased susceptibility to infections
Complications: Untreated Cushing s disease can lead to bone fractures, hypertension, full-blown infections, kidney stones, etc.

Treatment: This would depend on the cause. If you are on long-term steroids, the dose would need to be adjusted. This should always be done under medical supervision, as it requires constant adjustment. Underlying tumours (pituitary or adrenal) need to be diagnosed and treated. There are other hormones too which come into the picture and need to be monitored.
2516 people found this helpful