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Apolipoprotein E Health Feed

Alzheimer's - Causes, Symptoms And Treatment!

MBBS Bachelor of Medicine and Bachelor of Surgery, DPM - Psychiatry
Psychiatrist, Gurgaon
Alzheimer's - Causes, Symptoms And Treatment!
With age, most body organs begin to deteriorate in their function. This happens to the brain also, thereby reducing the overall speed of functioning of most organs. While slowing of bodily movement is visible, the internal organs functioning also slows down, which is not that obvious. Memory loss or dementia is one of the main manifestations of this degeneration of the brain.

Alzheimer s is the most common form of dementia, and the associated symptoms includes reduced reasoning abilities and cognitive defects. Though it is seen only in the elderly, not all elderly people will have Alzheimer s. The overall quality of life of the affected person is reduced with difficulty remembering things that were recently learned. It is a progressive disease and as it gets more severe, a full-time caretaker may be required.

Causes: The brain cells are affected by protein masses known as plaques and tangles. These hamper the way communication between the brain cells happens as well as affect nutrition from reaching all parts of the brain. This leads to shrinking of the brain, eventually leading to memory loss and other problems. There is also a strong genetic linkage, as most people with Alzheimer s have the lipoprotein A gene.

Symptoms: Though memory loss is the most common symptom, there are other symptoms:

Being confused about places, people, and times
Inability to find the right words during conversations
Regular objects are misplaced
Becoming irritable, (in someone who was not so previously)
Mood swings
Personality changes
Inability to organise thoughts
Not able to make the right decisions
Repetitive talks and actions
Forgetfulness (not something the person always does)
Difficulty with numbers (again, not something calculations
Difficulty managing everyday tasks and minor problems
Suspicion of others (like immediate family members and friends)
Risk factors: While age is definitely a risk factor, the fact that not all aged people develop Alzheimer s is to be borne in mind. Other risk factors include the history of stroke, high cholesterol, high blood pressure, diabetes, smoking, obesity, and poor lifestyle choices.

Diagnosis: While there is no definitive way to diagnose Alzheimer s, symptoms along with brain scans and neuropsychological function testing are useful ways to confirm the diagnosis.

Treatment: This is aimed at two things reducing the rate of disease progression and treat (or reverse) symptoms if possible.

Cholinesterase inhibitors improve cellular communication in the brain and also manage depression and agitation. Memantine is used to slow the pace of disease progression.
In people with the disease, small changes are useful to help them with the symptoms. These include keeping essential things like keys and wallet in the same place, keep a daily diary to help them remember things, keep pictures of friends and family within visible distance.
2195 people found this helpful

Why Is Vitamin B12 Important For Your Health?

ACSM Certified Personal Trainer, Specialist In Fitness Nutrition, PG Diploma In Weight Management
Dietitian/Nutritionist, Mumbai
Why Is Vitamin B12 Important For Your Health?
The human body requires the basic nutrients for its normal functioning which are carbohydrates, fats and proteins. However, there are certain vital vitamins and minerals too, that are equally important because these help in maintaining the proper health of a human body in various ways. One such vitamin is Vitamin B complex of which, there is a crucial vitamin known as Vitamin B12 or scientifically called as Cobalamin.

Functions of Vitamin B12: Vitamin B12 plays a major role by controlling several factors of the human body. These are necessary for the body to run well and stay healthy. Some of the key functions of Vitamin B12 are listed below:

It is responsible for the conversion of raw carbohydrate matter that enters into the body in the form of food into glucose that is the driving energy for the body. Therefore, in a way it helps to keep the continuity of energy production in the human body and its deficiency, therefore, can lead to fatigue or weakness.
Every single nature of human cells is related to the DNA and RNA that define the genetics and hereditary factors of a human body. Vitamin B12 assists in the creation of this DNA and RNA.
Vitamin B12 also helps in the production of nerve cells in the human body by maintaining the covering of the nerve cells or neurones known as the myelin sheaths. This helps to free the body from the reach of toxins and free radicals that can be very harmful to the human body. Hence, any shortage of Vitamin B12 can damage the nerve cells in a considerable manner.
The bones of the human body need Vitamin B12 as well and any deficiency of Vitamin B12 can cause osteoporosis and other bone issues.
Vitamin B12 in association with another vitamin known as Vitamin B9 (folate or folic acid) helps in the manufacture of red blood cells that help in impressive iron functioning, which is the main oxygen carrier of the human blood. Quite evidently, its deficiency can lead to shortness of breath and other breathing disorders.
Even heart requires an adequate amount of Vitamin B12 along with Vitamin B6 and Vitamin B9 so that appropriate levels of amino acid named homocysteine are produced that is a deciding factor in heart diseases.
Vitamin B12 is an essential component affecting the brain health too, and any deficiency of Vitamin B12 can often lead to various brain disorders such as Alzheimer s disease and the like.
In fact, Vitamin B12 has also been found to regulate mood and emotions of humans. Above all, Vitamin B12 is vital for keeping an individual happy and healthy by revitalising the body cells and making him or her feel youthful and vibrant all the time.
2471 people found this helpful

Hi, My father has alzheimer's for the last 5 yrs. And it is getting worse with time. He hardly sleeps at night, nor does he let others at home sleep. It has become a huge problem for us to handle him and has started to affect my work due to sleep depravity. Are there any generic medicines that we can give him so he sleeps more? Also any other vital input regarding handling people with Alzheimer's would be greatly appreciated.

M.D.PSYCHIATRY, Bachelor of Medicine, Bachelor of Surgery (M.B.B.S.), Medicine
Psychiatrist, Jaipur
Hi, My father has alzheimer's for the last 5 yrs. And it is getting worse with time. He hardly sleeps at night, nor d...
HI lybrate-user. Unfortunately Alzohmers is progressive diesase. Your father has behavioural and psychological symptoms of diesase. He could be started on low dose mediciness to calm him down. Some therapies like music, art, dance, aroma etc also proven to be somewhat effective. You can try it.
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Alzheimer's Disease - Causes, Symptoms And Treatment!

DM - Neurology, MBBS, MD - Medicine
Neurologist, Bhubaneswar
Alzheimer's Disease - Causes, Symptoms And Treatment!
Alzheimer s disease is a neurological, irreversible, progressive brain disorder. It is a chronic neurodegenerative dementia that causes the death of brain cells, causing memory loss and cognitive decline. It affects a person s thinking and behavior. The symptoms develop slowly and get worse as time passes.

Causes:
As it is a kind of dementia, Alzheimer s is caused by the death of brain cells. Over a course of time, brain cells die progressively and at the end, the tissue is left with fewer nerve cells and connections. As a result, the total brain size shrinks. Tiny inclusions called plaques and tangles can be seen in the postmortem. These cannot be seen or tested in a living Alzheimer s affected brain. These plaques are given the name amyloid plaques because they are found among the dying cells of the brain when a protein called beta-amyloid builds. The tangles stay in the neurons; they are formed from a protein called tau.

There are several reasons behind all this, some of which are listed below-

Anti-anxiety medications
Hitting on the head too many times
Regularly sleep-deprived
Loneliness
Diabetes in the brain
Old age
Genetic line
Down s syndrome
Cardiovascular diseases
Symptoms:
Alzheimer s disease damages the brain, so the clinical signs and symptoms begin to show very early. The symptoms are-

Memory loss
Agitation and mood swings
Poor judgment
The trouble with money calculations
Difficulty doing familiar tasks
Trouble in planning or solving a problem
Confusion with time and place
Difficulty in communicating
Loss of motivation
Inappropriate behavior
Aggressive personality
Childlike behavior
Preventing Alzheimer s disease:
Alzheimer s disease ultimately results in death. Even if there are treatments, they cannot fully cure it. So it s better to try to prevent it before it happens. Ways to prevent Alzheimer s disease are-

Eating more fruits and vegetables.
Eating berries every day.
Increasing omega-3 fatty acids.
Taking folic acid supplements.
Drinking grape juice or red wine with evening meal.
Doing the Mediterranean style diet.
Controlling the blood pressure.
Having strong social support.
Treatment of Alzheimer s disease:

Treatment of Alzheimer s disease is a long time process.
First of all, doctors perform a physical exam to check the overall neurological health. By this, they check muscle strength, reflexes, walking ability, sense of sight and hearing, coordination and balance.
Then comes the blood test to find the cause of confusion and memory loss by checking the thyroid disorder and vitamin deficiency.
Then they perform the neuropsychological test and check the mental status.
Then there are other tests, like MRI, CT, and PET.
After all this, drugs are given and a safe and supportive environment is created with proper exercise and nutrition.
1730 people found this helpful

How Physiotherapy Can Help Treat Dementia?

MPTh/MPT, BPTh/BPT
Physiotherapist, Vadodara
How Physiotherapy Can Help Treat Dementia?
Dementia is a general classification of a brain disease that causes a long haul and frequently steady abatement in the capacity to think and recall that is sufficiently incredible to influence a man's everyday functioning. Other normal manifestations incorporate passionate issues, issues with dialect, and a lessening in motivation. An individual's awareness is not influenced. The most common example of dementia is the Alzheimer's disease.

Physiotherapy for Dementia:
A patient with dementia can benefit from physiotherapy regardless of the possibility that the patient can't perceive their own family. Physiotherapy, notwithstanding, can be of good advantage to the individual who has dementia and also their family and parental figures at different stages. The principle explanation behind this is that recovery administrations can help the dementia patient to be as utilitarian as would be prudent for whatever length of time that is conceivable. Here are 5 ways physiotherapy benefits an Alzheimer's patient:

Physiotherapy can keep up the Alzheimer's patient's freedom and mobility as much as one could expect reasonably. A physiotherapist can outline a home activity program and work intimately with relatives to administer to the Alzheimer's patient.
Physiotherapists, as independent experts, embrace much detailed, separately custom-made appraisals of the disorders, action confinements and restrictions imposed upon individuals with dementia.
The caretakers of individuals with dementia regularly show weakness when contrasted with their same aged companions. Physiotherapy helps with diminishing the weight of consideration by instructing caregivers to provide encouragement and upliftment to individuals with dementia.
Patients with dementia are always at a risk of falling down and hurting themselves. Poor balance accounts for the danger of falls. This can be worked upon and improved by physiotherapy driven exercises. Exercise can have a huge and positive effect on behavioral and mental indications of dementia, enhancing psychological capacity and mindset, which can decrease the doses of strong medicines. Special exercise routines are assigned to the patients which help improve their body balance while walking.
Physiotherapy has crucial influence in advancing and keeping up portability of individuals with dementia. It assumes a basic part in the end of life consideration by overseeing situations, seating and complicated muscle contracture. Individuals with dementia regularly experience issues in communicating pain. Pain influences cognizance, inspiration and reaction to any intervention. Physiotherapists are specialists in recognizing and treating pain in dementia patients and give training to care home staff and caregivers of the patients.
Physiotherapy is very important for dementia patients. Regular physiotherapy sessions are beneficial for patients for improvement in condition.
2216 people found this helpful

Alzheimer's Disease - Know How Immune System Triggers It!

DM - Neurology, Fellowship in Stroke Neurology, MD - General Medicine, MBBS Bachelor of Medicine and Bachelor of Surgery
Neurologist, Kolkata
Alzheimer's Disease - Know How Immune System Triggers It!
Alzheimer's Disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of Alzheimer's Disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of Alzheimer's Disease. The main causes of Alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: Many a times, in Alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: The brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called Amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern Recognition Receptors: Many of these receptors work in different manners and cooperate with each other to create a response in the brain. These PRRs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of Cells Linked with the Immune System: When the PRRs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case Alzheimer's Disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of Alzheimer's Disease before it progresses beyond one's control.
2860 people found this helpful

Causes And Treatment Of Alzheimer's

MBBS, MD - Neuropsychiatry
Psychiatrist, Varanasi
Causes And Treatment Of Alzheimer's
With age, most body organs begin to deteriorate in their function. This happens to the brain also, thereby reducing the overall speed of functioning of most organs. While slowing of bodily movement is visible, the internal organs functioning also slows down, which is not that obvious. Memory loss or dementia is one of the main manifestations of this degeneration of the brain.

Alzheimer s is the most common form of dementia, and the associated symptoms includes reduced reasoning abilities and cognitive defects. Though it is seen only in the elderly, not all elderly people will have Alzheimer s. The overall quality of life of the affected person is reduced with difficulty remembering things that were recently learned. It is a progressive disease and as it gets more severe, a full-time caretaker may be required.

Causes: The brain cells are affected by protein masses known as plaques and tangles. These hamper the way communication between the brain cells happens as well as affect nutrition from reaching all parts of the brain. This leads to shrinking of the brain, eventually leading to memory loss and other problems. There is also a strong genetic linkage, as most people with Alzheimer s have the lipoprotein A gene.

Symptoms: Though memory loss is the most common symptom, there are other symptoms:

Being confused about places, people, and times
Inability to find the right words during conversations
Regular objects are misplaced
Becoming irritable, (in someone who was not so previously)
Mood swings
Personality changes
Inability to organise thoughts
Not able to make the right decisions
Repetitive talks and actions
Forgetfulness (not something the person always does)
Difficulty with numbers (again, not something calculations
Difficulty managing everyday tasks and minor problems
Suspicion of others (like immediate family members and friends)
Risk factors: While age is definitely a risk factor, the fact that not all aged people develop Alzheimer s is to be borne in mind. Other risk factors include the history of stroke, high cholesterol, high blood pressure, diabetes, smoking, obesity, and poor lifestyle choices.

Diagnosis: While there is no definitive way to diagnose Alzheimer s, symptoms along with brain scans and neuropsychological function testing are useful ways to confirm the diagnosis.

Treatment: This is aimed at two things reducing the rate of disease progression and treat (or reverse) symptoms if possible.

Cholinesterase inhibitors improve cellular communication in the brain and also manage depression and agitation. Memantine is used to slow the pace of disease progression.
In people with the disease, small changes are useful to help them with the symptoms. These include keeping essential things like keys and wallet in the same place, keep a daily diary to help them remember things, keep pictures of friends and family within visible distance.

Hi. How much exercise should I do to keep my heart stronger ? I've heard that too much (vigorous exercise) is harmful for heart. What kind of exercise should I do ? Is walking or swimming for 30 to 40 minutes a day is safe n sufficient for a strong heart Please guide.

Ph.D(Clinical Nutrition), M.Sc(Foods&Nutrition
Dietitian/Nutritionist, Delhi
Hi.
How much exercise should I do to keep my heart stronger ?
I've heard that too much (vigorous exercise) is harmful...
Yes 40-50 min swimming, brisk walk, dance ,aerobics daily is sufficient and safe. If anyone has a heart ailment already, he should go by the cardiologists advice.
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What are the long term effects of ecosprin overdose? What if the victim takes 15nos of ecosprin at a time.

NCCH & MCH
Homeopath, Kolkata
What are the long term effects of ecosprin overdose? What if the victim takes 15nos of ecosprin at a time.
Don't use much it will lead to anaplastic anaemia even blood cancer in long go. kindly consult back for proper guidance and treatment.
1 person found this helpful
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Aged 73 male, I am prescribed rosuvas gold 20 mg inditel 25 mg dytor 5 for concentric LVH ,PML TIP CALCIUM AND dilated LA.

MD - Homeopathy, BHMS
Homeopath, Vadodara
Aged 73 male, I am prescribed rosuvas gold 20 mg inditel 25 mg dytor 5 for concentric LVH ,PML TIP CALCIUM AND dilate...
You can consult me through Lybrate for homoeopathic treatment.. Allopathic treatment will give temporary relief only..
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