Epidermodysplasia Verruciformis is an autosomal recessive genetic disorder related to the skin. It is commonly referred to as three man illness. People affected with Epidermodysplasia Verruciformis have a high susceptibility towards developing carcinoma of the skin. Also there is greater susceptibility towards human papillomaviruses of the skin. Symptoms are:
• Lifelong eruptions pityriasis versicolor-like macules
• Flat wart-like lesions
• Pink to violet coloured flat-topped papules
• Raised brown colored lesions in sun-exposed skin
HOW IS EPIDERMODYSPLASIA VERRUCIFORMIS DIAGNOSED?
The diagnosis of this condition is usually done by the general physician with the help of skin tests where sample tissue will be extracted from the lesions to study the same under a microscope and find the presence of the faulty carrier gene with a series of tests. Also, other lab tests based on the blood samples will help in this endeavour.
HOW IS EPIDERMODYSPLASIA VERRUCIFORMIS TREATED?
Currently there is no treatment to prevent new EV lesions from occurring. The management of EV involves a combination of medical and surgical treatments alongside patient counselling and education. Focus on the importance of following sun protection strategies. Treat and remove warts, as one would treat other viral warts. This includes chemical treatment, cryotherapy with liquid nitrogen and electrosurgery. Oral and topical treatments with retinoic are also helpful in treating the disorder.
DID YOU KNOW?
It is a lifelong disease. Even though lesions can be treated or removed as they appear, patients will continue to develop these lesions throughout life. In many cases lesions may develop and remain unchanged for years. The greatest risk is that in 30-60% of patients with these lesions will change into skin cancers. Malignant tumors are usually found in patients between 30-50 years of age.