X-linked ichthyosis is a genetic skin disorder that affects males. It is an inborn error of metabolism characterized by a deficiency of the enzyme steroid sulfatase. Under normal conditions, this enzyme breaks down (metabolizes) cholesterol sulfate, a member of the chemical family of steroids. Cholesterol sulfate plays a role in maintaining the integrity of the skin. If steroid metabolism is interrupted and cholesterol sulfate accumulates in the skin cells, the skin cells stick together more strongly than usual. The normal shedding of dead skin cells is inhibited and the skin cells build up and clump into scales.
HOW IS X-LINKED ICHTHYOSIS DIAGNOSED?
Diagnosis of the X-linked Ichthyosis is done through genetic testing and also doing a skin examination.
HOW IS X-LINKED ICHTHYOSIS TREATED?
X-linked Ichthyosis responds well to topical treatment with alpha-hydroxy acids. These applications slow down the shedding of the stratum corneum. Emollients are also useful in treating X-linked Ichthyosis
DID YOU KNOW?
People who have suffered from this problem should consult a genetical expert prior to planning a baby as he/ she may get it to.