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The condition where large painful ulcers or sores develop on the skin especially on the leg is known as pyoderma gangrenosum. These sores would start as a small red bump on the skin which would quickly develop into an ulcer.
HOW IS PYODERMA GANGRENOSUM DIAGNOSED?
Pyoderma gangrenosum is diagnosed by its characteristic appearance. There is no specific test. The wound should be swabbed and cultured for micro-organisms, but these are not the cause of pyoderma gangrenosum. Biopsy may be necessary to rule out other causes of ulceration. Pyoderma gangrenosum characteristically results in a neutrophilic inflammatory infiltrate but this is not always present. The pathergy test is usually positive (a skin prick test causing a papule, pustule or ulcer).
HOW IS PYODERMA GANGRENOSUM TREATED?
First-line therapy for localized instances of pyoderma gangrenosum is systemic treatment by corticosteroids and ciclosporin. Topical application of clobetasol, mupirocin, and gentamicin alternated with tacrolimus can be effective.Papules that begin as small ""spouts"" can be treated with Dakin's Solution to prevent infection and entire wounds cluster also benefit from this disinfectant. Wet to dry applications of Dakin's can defeat spread of interior infection. Heavy drainage can be offset with Coban dressings.
DID YOU KNOW?
The cause of pyoderma gangrenosum is unknown but individuals that have rheumatoid arthritis or inflammatory bowel disease are at a greater risk of contracting it.