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Doctors for Pseudoxanthoma Elasticum in Sobermutt Galli, Hubli-Dharwad
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Pseudoxanthoma Elasticum (PXE) is a progressive disorder that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers i.e. components of connective tissue which provide strength and flexibility to structures throughout the body. People suffering from Pseudoxanthoma Elasticum may have yellowish bumps called papules on their necks, underarms and other areas of skin that touch when a joint bends. Some of the common signs of Pseudoxanthoma Elasticum include skin changes, changes in the retina of the eye that may lead to loss of central vision, decreased blood flow in the arms and legs and changes in the gastrointestinal system that may lead to bleeding in the stomach.
HOW IS PSEUDOXANTHOMA ELASTICUM DIAGNOSED?
Changes in the skin are typically the earliest sign of Pseudoxanthoma Elasticum and allow the Dermatologist to diagnoses Pseudoxanthoma Elasticum. However, in some cases, the doctor conducts a small biopsy of a lesion to confirm the diagnosis of Pseudoxanthoma Elasticum.
HOW IS PSEUDOXANTHOMA ELASTICUM TREATED?
There is no treatment that directly interferes with the disease process, although dietary restriction of calcium has been tried with limited results. For excessive areas of skin, plastic surgery may be needed. For the growth of abnormal blood vessels in the retina, laser photocoagulation and photodynamic therapy may be used, injections with triamcinolone have shown limited effect. Antiangiogenic drugs such as bevacizumab (Avastin) and ranibizumab (Lucentis) have been effective, similar to its efficacy in age-related macular degeneration. Cardiovascular disease is treated as in individuals without PXE. Some recommend avoidance of nonsteroidal anti-inflammatory drugs that increase bleeding risk, such as aspirin and ibuprofen.
DID YOU KNOW?
Such patients need constant monitoring to prevent these bumps from getting deeper and causing internal damage to organs and tissues.