Li-Fraumeni Syndrome is a rare inherited hereditary cancer disorder that increases one’s risk of developing cancer during their lifetime. Often, people with Li-Fraumeni Syndrome develop multiple tumors or multiple cancers.
HOW IS LI-FRAUMENI SYNDROME DIAGNOSED?
An Oncologist/Homeopath usually diagnoses Li-Fraumeni Syndrome with the patient’s medical history and a physical examination. Also, further tests are conducted to detect Li-Fraumeni Syndrome such as biopsy, CT scan, MRI and an adrenal angiography.
HOW IS LI-FRAUMENI SYNDROME TREATED?
Li-Fraumeni Syndrome influences certain people to multiple different types of cancer and often multiple cancers and multiple tumors over their lifetime. Routine oncologic management is recommended for malignancies in individuals with LFS, with the exception of breast cancer, in which mastectomy rather than lumpectomy is recommended in order to reduce the risks of a second primary breast tumor and avoid radiation therapy. Concerns about increased risk for radiation-induced second primary tumors has led to more cautious use of therapeutic radiation in general, but most experts recommend that treatment efficacy be prioritized above concerns about late effects after careful analysis of risks and benefits.
DID YOU KNOW?
The lifetime risk for a person with LFS to develop any type of cancer is 90%. Approximately 50% of these cancers will be diagnosed before age 30. In a study of 200 people with a TP53 gene mutation who had a previous diagnosis of cancer, 15% developed a second, 4% developed a third cancer and 2% developed a fourth cancer, with the highest risk of additional cancers being in those diagnosed with their first cancer during childhood. However, some people with LFS will never develop cancer.