Familial Hyperinsulinemic Hypoglycemia is a condition that is signified with extreme cases of low sugar or hypoglycaemia. This problem usually is seen in infants and is owed to the due to endogenous insulin. In most cases, there is an acute damage to the brain and everyday activities are hampered too. The development is delayed and in adults it means strokes and other similar issues.
HOW IS FAMILIAL HYPERINSULINEMIC HYPOGLYCEMIA DIAGNOSED?
The pediatrician does the diagnosis of the disorder. The doctor will perform a physical examination and ask for details of medical history and family history. Babies with neonatal hyperinsulinism are often large for gestational age and may have other features such as enlarged heart and liver. Knowing that someone takes insulin or oral hypoglycemic agents for diabetes obviously makes insulin excess the presumptive cause of any hypoglycemia. Blood and urine tests are recommended for further diagnosis.
HOW IS FAMILIAL HYPERINSULINEMIC HYPOGLYCEMIA TREATED?
Initially hypoglycemia is treated by injecting glucagon intramuscularly or intravenously or dextrose can be infused. Hypoglycemia due to drug overdose or effect is supported with extra glucose until the drugs have been metabolized. The drug doses or combination often needs to be altered. Hypoglycemia due to a tumor of the pancreas or elsewhere is usually curable by surgical removal. Most of these tumors are benign. Hyperinsulinism due to diffuse overactivity of beta cells, such as in many of the forms of congenital hyperinsulinism, and more rarely in adults, can often be treated with diazoxide or a somatostatin analog called octreotide. Diazoxide is given by mouth, octreotide by injection or continuous subcutaneous pump infusion. When congenital hyperinsulinism is due to focal defects of the insulin-secretion mechanism, surgical removal of that part of the pancreas may cure the problem. In more severe cases of persistent congenital hyperinsulinism unresponsive to drugs, a near-total pancreatectomy may be needed to prevent continuing hypoglycemia. Even after pancreatectomy, continuous glucose may be needed in the form of gastric infusion of formula or dextrose.
DID YOU KNOW?
Aggressive prevention of hypoglycaemia helps prevent brain damage.