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Doctors for Common Variable Immunodeficiency in Siddharameshwar Nagar, Hubli-Dharwad
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COMMON VARIABLE IMMUNODEFICIENCY
Common Variable Immunodeficiency (CVID) is an antibody deficiency that leaves the immune system unable to defend against bacteria and viruses, resulting in recurrent and often severe infections from foreign invaders such as bacteria, or more rarely, viruses and often develop recurrent infections, particularly in the lungs, sinuses, and ears.
HOW IS COMMON VARIABLE IMMUNODEFICIENCY DIAGNOSED?
A specialist from the Immunology department or the general physician will usually carry out the diagnosis based on the symptoms. A physical examination as well as several lab tests to check the blood and urine will be carried out. The IgG, IgA and other related levels will be checked for diagnosis.
HOW IS COMMON VARIABLE IMMUNODEFICIENCY TREATED?
Treatment consists of immunoglobulin replacement therapy, which replenishes Ig subtypes that patients lack. This treatment is given at frequent intervals for life and is thought to help reduce bacterial infections and boost immune function. Before therapy begins, plasma donations are tested for known blood-borne pathogens, then pooled and processed to obtain concentrated IgG samples. Infusions can be administered in three different forms: intravenously (IVIg): subcutaneously (SCIg), and intramuscularly (IMIg). The administration of intravenous immunoglobulins requires the insertion of a cannula or needle in a vein, usually in the arms or hands. Because the highly concentrated product is used, IVIg infusions take place every 3 to 4 weeks. Subcutaneous infusions slowly release the Ig serum underneath the skin, again through a needle, and takes place every week. Intramuscular infusions are no longer widely used, as they can be painful and are more likely to cause a patient reaction.
DID YOU KNOW?
CVID has an estimated prevalence of about 1,50,000 in Caucasians