Induction therapy is recommended after renal transplantation to prevent rejection. The therapy provides a high degree of immunosuppression at the time of transplantation. Induction therapy is often considered essential to increase the chances of easy acceptance. Induction therapy adopts a multi-pronged approach comprising several medications that act on different areas of the immune system. The therapy can be broadly categorized into three stages including induction therapy, maintenance therapy, and treatment of an acute rejection episode.
Induction therapy is usually started during or immediately after the transplant and is concluded within the first week or two. The therapy is not a compulsory requirement however, it is considered essential to smooth acceptance of the newly received organ, particularly in individuals having a high risk of rejection, recipients with a history of transplantation, and those receiving a calcineurin inhibitor.
There is no specified regimen for induction therapy, it may vary among individual patients. The type of induction therapy suitable for a transplant recipient depends on pre-existing medical conditions, donor characteristics, and the maintenance therapy that is being employed for the patient. One strategy relies upon high doses of conventional immunosuppressive agents, while the other utilizes antibodies directed against T-cell antigens in combination with lower doses of conventional agents. The immunosuppressive agents generally used are either monoclonal or polyclonal antibodies.
The introduction of medications for the initiation of immunosuppression has reduced the frequency of acute rejection in patients.
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