Thrombotic thrombocytopenic purpura (TTP or Moschcowitz syndrome is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body.These small blood clots, called thrombi, can damage many organs including the kidneys, heart and brain. Symptoms may include any of the following:
• Bleeding into the skin or mucus membranes
• Fatigue, weakness
• Pale skin color or yellowish skin color
• Shortness of breath
• Fast heart rate (over 100 beats per minute)
HOW IS THROMBOTIC THROMBOCYTOPENIC PURPURA DIAGNOSED?
A general physician will diagnose the condition based on a physical examination followed by tests such as ADAMTS 13 activity level, bilirubin, blood smear, CBC, Creatinine level, platelet count, urinalysis and other lab tests that may be necessary.
HOW IS THROMBOTIC THROMBOCYTOPENIC PURPURA TREATED?
Doctors treat TPP by attempting to return your blood clotting ability to normal. The usual treatment for inherited TTP is to administer plasma intravenously, or through an IV. An alternative treatment is plasma exchange from a healthy donor replaces one’s plasma. If the plasma treatment isn't successful, doctor may begin to treat with medications to stop body from destroying the ADAMTS13 enzyme. In rare cases, your spleen might need to be surgically removed.
DID YOU KNOW?
Complications may include:
• Kidney failure
• Low platelet count (thrombocytopenia)
• Low red blood cell count (caused by the premature breakdown of red blood cells)
• Nervous system problems
• Severe bleeding (hemorrhage)