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Overview

Ilaprazole

Prescription vs OTC : Prescription by Doctor required

About Ilaprazole

Belonging to a cluster of drugs known as PPIs, Ilaprazole is used for reducing the acid content in the stomach. This drug treats duodenal or gastric ulcers, Gastroesophageal Reflux Disease (GERD), inflammation of the esophagus and conditions wherein the stomach secretes excess acid.

Ilaprazole is prescribed as the short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment.

Also, it is given in the treatment of heartburn and other symptoms associated with GERD; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; maintenance of healing of erosive esophagitis.

This medicine is approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer. The most common side effects associated with Ilaprazole include diarrhea, gas, vomiting, headache, nausea and stomach aches.

Although rare, certain severe adverse reactions are increased possibility of bone fractures, decreased magnesium levels inside the body, seizures, irregular heart-beats, jitteriness, muscle spasms and weakness, feet/hand spasms, voice box spasms, etc.

The likelihood of these severe side effects goes up if you take this medicine for over a period of 3 months. Also, prolonged intake of this medication (usually over a period of three years) can result in your body’s decreased ability to absorb Vitamin B12.

Other possible (albeit rare) side effects include diarrhea, inflammation of the intestine and the stomach lining, damage to the kidneys, allergic reactions, weight loss, and fever.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the uses of Ilaprazole

    • Gastroesophageal Reflux Disease

    • Zollinger-Ellison Syndrome

    • Duodenal Ulcer

    • Helicobacter Pylori Infection

    • Erosive Esophagitis

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the contraindications of Ilaprazole ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the side effects of Ilaprazole ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    Key highlights of Ilaprazole

    • Is It safe with alcohol?

      Taking a large amount of alcohol can increase acidity and cause acid reflux in the food pipe causing heartburn. This would decrease the effect of this drug and can aggravate your underlying condition.

    • Are there any pregnancy warnings?

      Unknown. Human and animal studies are not available. Please consult your doctor.

    • Are there any breast-feeding warnings?

      Unknown. Human and animal studies are not available. Please consult your doctor.

    • Is it safe to drive while on this medicine?

      There is no interaction between driving and consuming this drug. So dose alteration is not needed.

    • Does this affect kidney function?

      There is no data available. Please consult doctor before consuming the drug.

    • Does this affect liver function?

      There is no data available. Please consult doctor before consuming the drug.

    • What is the onset of action?

      The peak effect of this medicine can be observed within 1 to 2 hours of administration.

    • How long is the duration of effect?

      This medicine is excreted primarily in urine and the effect of this medicine lasts for a duration of 48 hours.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      If you miss a dose of Ilaprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    Medicines containing Ilaprazole

    Below is the list of medicines, which contains Ilaprazole as ingredient

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

    How does this medication work?

    This medication belongs to the class of proton-pump inhibitor which works by suppressing the secretion of gastric acid by specifically inhibiting the H+/K+-ATPase enzyme in the gastric parietal cells. Inhibition of this enzyme and blocking of the proton pump blocks the acid formation pathway, reducing gastric acid production.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

      What are the interactions of Ilaprazole ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Medicine

        Concomitant use of this medicine along with following must be avoided:
        • Ketoconazole: The desired effect of Ketoconazole and other antifungal agents of the same class will not be achieved when taken with Omeprazole. Inform the doctor about the usage of either of these medications so that safer alternatives can be prescribed.
        • Methotrexate: It is not recommended to take Omeprazole with methotrexate. This combination will increase the concentration of methotrexate in the blood and can produce serious side effects. Inform the doctor if you are taking these medicines simultaneously. An alternate medicine should be considered based on your clinical condition.
        • Warfarin: Omeprazole should be used with caution in you are also taking warfarin. If co-administration is needed, then regular monitoring of prothrombin time, unusual bleeding, the presence of blood in urine is necessary. Appropriate dose adjustments are to be made under doctors supervision.
        • Nelfinavir: The desired effect of anti-viral medications like Nelfinavir will not be obtained when taken with Omeprazole. Inform the doctor if you are taking these medicines simultaneously. An alternate medicine should be considered based on your clinical condition.
      • Interaction with Disease

        Osteoporosis

        The risk of bone fractures is more if you are on high doses and long-term therapy. Use with caution if you are at risk of developing bone fractures and lower doses for a short duration of time should be considered.

      FAQs about Ilaprazole

      • Ques : What is Ilaprazole used for?

        Ans : Ilaprazole is used in the treatment of GERD that is, gastro-oesophagal reflux disorder and peptic ulcer as well as dyspepsia.

      • Ques : Should Ilaprazole be taken with a meal or without a meal?

        Ans : It is advised to take Ilaprazole with a meal for better effectiveness.

      • Ques : Is Ilaprazole safe for usage in paediatrics?

        Ans : Ilaprazole is not recommended for usage in paediatrics as its safety and effectiveness are not known.

      • Ques : What is the route of administration of Ilaprazole?

        Ans : Ilaprazole can be administered both orally and paternally.

      • Ques : What are the storage indications of Ilaprazole?

        Ans : Ilaprazole should be stored at room temperature away from direct heat and humidity.

      • Ques : What are the dietary specifications while taking Ilaprazole?

        Ans : There are no specific dietary specifications while taking Ilaprazole unless the doctor instructs otherwise.

      • Ques : What is Ilaprazole?

        Ans : Ilaprazole is a medicine belonging to the class of PPI, that is, Proton pump inhibitor and helps to alleviate acidity related health issues.

      References

      • Ilaprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 25 Nov 2021]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/ilaprazole

      • Ilaprazole - DrugBank [Internet]. Drugbank.ca. 2021 [cited 3 December 2021]. Available from:

        https://go.drugbank.com/drugs/DB11964

      • Ilaprazole - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2021 [cited 03 December 2021]. Available from:

        https://pubchem.ncbi.nlm.nih.gov/compound/214351

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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