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Melanoma is a condition which mainly indicates a severe malfunction of the melanocytes or the melanin producing cells of the body. These cells are responsible for giving you your skin colour, tone and complexion. Usually, a person suffering from melanoma will have many normal and irregular moles as well as melanoma in the eye and digestive tracts too.
Some general facts on melanoma are mentioned below:
Melanoma is common in young women and causes many deaths.
More than one million new instances of skin cancer or melanoma are analyzed every year.
There has been a 2000% increase in rate of melanoma since the year 1930. One out of fifty get affected by this cancer.
There has been a high rise in the rate of melanoma from 1970 to 2008. There has been an 800% increase in young women and 400% increase in case of similar aged men.
Early recognition makes melanoma treatable. It is screened for growth very minimally.
Primary causes Melanoma may be caused primarily due to these causes:
The most primary cause of melanoma is ultraviolet light (UV) in people with a low level of skin pigment. The UV light might be from either the sun or from different sources, for example, tanning devices. Around 25% of cases occur from or in the form of moles.
The individuals who work on airplanes seem to have an expanded danger, due to more contact with UV rays.
Ultraviolet UV light of wavelengths between 315 - 280 nm from the sun react with the skin cell DNA and result in a kind of direct DNA harm called cyclobutane pyrimidine dimers (CPDs).
In order to stay away or avoid melanoma, you should:
Avoid the sun at peak hours.
Examine your skin at times for some kind of change.
Keep away from tanning salons. Melanoma is a dangerous form of cancer and causes a lot of deaths. You should stay away from anything that causes melanoma. If you wish to discuss about any specific problem, you can consult a doctor and ask a free question.
Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.
Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.
The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.
However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se.
Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss about any specific problem, you can consult a Sexologist.