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If I want to use Viagra for one time only is it make any side effect, also tell me which is best to use.
Hello Doctor, My doctor prescribed me hair 4 you 2% lotion because of improper hair growth & also advised not to use during pregnancy. Actually we are planning for our baby after 2 to 3 months .so now my concern is should I use it before pregnancy or not? Will it affect to my baby? Really need your help. Thanks.
Hello lybrate Medical Devotees, Thanks for your previous support. I need an urgent suggestion regarding my query asap. Actually my friend suddenly started having intense body pain followed by high fever, cold and hoarse voice. After check up, She found her BP 135/70. Still she is suffering from high fever and body pain. Please do help me with my query. ASAP.
I am a male of 22 yrs. I feel stress because I always think about my face. Becoz it is dull and now I am taking medicine for my dull face according to dermatologist. Treatment taking too much time. I always think that people do not like me. How should I change my mentality?
Sir, Im an engineering student and study 7-8 hrs a day. Sir I am observing since last 2-3 years that hairs are getting white at top of my head My parents r now 45 n now they had Started to get there hairs white but for me it has been started even before 20 years. Sir pls suggest me some help ,either in form of yoga or oil type so that I could get rid of this problem. Also I wanted to know that whether using altering hair oil types adversely affects our hair? Thanks.
I am having the pimples problem and the marks on my face due this pimple are very annoying. How to get rid of these pimples.
Dengue fever is a disease caused by mosquitoes which mostly occurs in tropical climates. Dengue hemorrhagic fever is a type of dengue fever that may lead to decrease in blood pressure and severe bleeding. Dengue may lead to death if the symptoms of this disease are not treated at the right time. The symptoms of this disease are high fever, muscle ache, pain in the eyes, pain in the abdomen and nausea. It may also lead to respiratory problems such as breathing difficulties. Presence of blood in the stool and blood spots around the skin are some other symptoms of dengue.
The symptoms of this disease start after 5 - 9 days after being bitten by the mosquito. The disease usually lasts about 7-8 days. In case the symptoms worsen, the disease may become life threatening.
The various methods you can employ to protect yourself from dengue are:
- Maintain cleanliness around your surroundings: Make sure you keep your surroundings clean so that mosquito infestations do not occur. Keep your surroundings clean and dry as mosquitoes thrive in moist and humid surroundings.
- Mosquito repellents: Spray mosquito repellents to keep your home free from mosquitoes. Spray them keeping the room locked to make it more effective. There are multiple types of repellents available such as liquid or gas repellents.
- Clothes: You should preferably wear full sleeved clothes so that your skin is not exposed. It provides additional protection from mosquito bites.
- Mosquito nets: Use mosquito nets to protect yourself from mosquitoes when you go to sleep at night. They also provide protection from other insects that may cause infections.
- Don't store waste: Don't store your waste products for long durations as they may turn into a breeding ground for mosquitoes. Clean it regularly and make sure to keep the area dry.
- Using natural remedies: You may use natural remedies such as burning camphor as it repels mosquitoes. Take camphor and burn it for 20 minutes in a closed room to get rid of the mosquitoes.
From last one month I am felling some pain and stress in the nerves of my feet every time I stretch my feet in forward direction.
If I wash my face n again it becomes oily within 2-3 minutes. My skin looks soo dull because of oiliness and sweat. please help me out plzz.
I am 22 years old boy and I have a hair fall problems from last 3 months. Please suggest me what should I do.
I have bp since last 15 years but now a days my bp is always 160/100 I take telmikind 40 after breakfast. I am a woman of 49 years. Pl advise diet & precautions to be taken.
I'm continuously having back pain from 5 days after sleeping on bed which was broken. Can you help me to get rid of this pain. I'm also getting the problem of gas.
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Skin whitening is the practice of using substances, mixtures, or physical treatments to lighten skin color. Skin whitening treatments work by reducing the content of melanin of the skin. Many agents have been shown to be effective in skin whitening.
Specific zones of abnormally high pigmentation such as lentigo spots, moles and birthmarks may be de-pigmented to match to the surrounding skin. In cases of vitiligo, unaffected skin may be lightened to achieve a more uniform appearance.
Discovery and design
Melanogenesis inhibitors have been discovered and developed through several methods, including: screening of synthetic chemical libraries (high-throughput screening is occasionally used), screening of plant extracts, computational (in silico) search, found as a side effect of previously known drugs and exploration of structural analogues of previously known tyrosinase inhibitors based on knowledge (in varying degrees) of their structure-activity relationship. Thus, the development and discovery of melanogenesis inhibitors illustrates many of the methods used in drug design. Some of the most potent competitive reversible tyrosinase inhibitors are synthetic compounds with a potency hundreds of times that of kojic acid.
Mechanisms of action
Melanin is the main substance responsible for the color of the skin. Melanin is class of dark polymers generated by the body through the process of melanogenesis. Among the melanin pigmenting the skin and hair, 2 types can be distinguished based on its chemical composition and biological route of synthesis: the black/brown eumelanin and the red/yellow pheomelanin. The variation of skin color among individuals is mostly because of variation of the content of melanin in the skin. Skin with little or no melanin is almost white. Other factors influence skin color in a lesser degree, including the amount of blood in blood vessels (because of the color of blood), skin thickness and content of carotenoids in skin.
Melanin in synthesized in melanosomes which are organelles produced in melanocytes. Melanocytes are cells dedicated to this function that are present in the skin, hair follicles, and other structures of the body. The synthesis of melanin (also called" melanogenesis" and" melanization") involves a chain of enzyme-catalyzed chemical reactions and non-enzyme-catalyzed reactions. The main precursor to melanin is l-tyrosine. The first step of melanogenesis is the conversion of l-tyrosine to l-dopa; this is the first and rate-limiting step and is catalized by the enzyme tyrosinase. Other enzymes involved in the synthesis include tyrosinase-related protein 1 (trp1) and tyrosinase-related protein 2 (trp2); trp2 is also known as" dopachorome tautomerase" (dct). L-tyrosine is taken by the melanocytes from the intercellular medium, then transported to the melanosomes. L-tyrosine is also synthesized within the melanocytes from l-phenylalanine by the enzyme phenylalanine-hydroxylas (pah)
Melanosomes are transferred to keratinocytes (the most abundant cell type in the skin). Most of the melanin of skin is found in keratinocytes. Additionally, melanocytes interact with keratinocytes through chemical signaling.