It is the most common form of hereditary stroke disorder, and is thought to be caused by mutations of the Notch 3 gene on chromosome 19. It may start with attacks of migraine with aura or subcortical transient ischemic attacks or strokes, or mood disorders between 35 and 55 years of age. The disease progresses to subcortical dementia associated with pseudobulbar palsy and urinary incontinence.
HOW IS CEREBRAL AUTOSOMAL DOMINANT ARTERIOPATHY DIAGNOSED?
An MRI scan or CT scan can be conducted to show the progression of the ailment. These kinds of screening tests will also show the presence of white lesions around the various cerebral vessels present in the brain. A blood test can also help look for the presence of the Notch 3 gene which brings about this condition.
HOW IS CEREBRAL AUTOSOMAL DOMINANT ARTERIOPATHY TREATED?
No specific treatment is available. However, antiplatelet agents such as aspirin, dipyridamole or clopidogrel might slow down the disease and help prevent strokes. Stopping oral contraceptive pills is advice. Aggressive treatment of hypertension and hypercholesterolemia is done.
DID YOU KNOW?
The cardiologist will help in treatment and diagnosis of the condition.