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Treatment Of Erectile Dysfunction
Treatment Of Male Sexual Problems
Skin Care Treatment
Treatment of Migraine Treatment
Treatment Of Female Sexual Problems
Sexually Transmitted Disease (Std) Treatment
Cysts Removal Procedure
Chronic Skin Allergy Treatment
Treatment Of Pregnancy Problems
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I am losing hair and some of them are turn into white please help me what I have to do to turn that white hair into black and suggest me chemical free shampoo.
I am 17 years old male and am trying to gain weight. I have joined gym but its not helping. I would like to know about the diet and exercises helpful in this regard.
Sir I'm having spots on my face I hv tried many tubes but no one didn't work. please suggest me for best idea or any tube & anything. To bring me out this problem, Thanx.
I'm working in night shift, after returning to home I can't sleep properly please suggest me what I can do and also suggest how to take care of my health.
I can not sleep at night. Idont know why. If I want to sleep I should take any drug or alcohol, masturbate.
Hi, doctor. Please help me getting a clear skin, I have pimples marks and very few chicken pox marks left on my face, my skin does not looks clear at a closer look, please suggest me any ointment or anything that could help getting a fair and clear face:) Thanks in Advance.
Some time while sleeping I'm in able to move my body and unable to breath properly and seems like dreaming what's this called?
Hairgro gel does it helps to grow beard And how much it costs in India and is there any side effects of using it.
Hi sir/Madam i am regularly using egg white to my hair can you please suggest me is it good or bad to my hair and what are the advantages of using egg to hair.
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Skin whitening is the practice of using substances, mixtures, or physical treatments to lighten skin color. Skin whitening treatments work by reducing the content of melanin of the skin. Many agents have been shown to be effective in skin whitening.
Specific zones of abnormally high pigmentation such as lentigo spots, moles and birthmarks may be de-pigmented to match to the surrounding skin. In cases of vitiligo, unaffected skin may be lightened to achieve a more uniform appearance.
Discovery and design
Melanogenesis inhibitors have been discovered and developed through several methods, including: screening of synthetic chemical libraries (high-throughput screening is occasionally used), screening of plant extracts, computational (in silico) search, found as a side effect of previously known drugs and exploration of structural analogues of previously known tyrosinase inhibitors based on knowledge (in varying degrees) of their structure-activity relationship. Thus, the development and discovery of melanogenesis inhibitors illustrates many of the methods used in drug design. Some of the most potent competitive reversible tyrosinase inhibitors are synthetic compounds with a potency hundreds of times that of kojic acid.
Mechanisms of action
Melanin is the main substance responsible for the color of the skin. Melanin is class of dark polymers generated by the body through the process of melanogenesis. Among the melanin pigmenting the skin and hair, 2 types can be distinguished based on its chemical composition and biological route of synthesis: the black/brown eumelanin and the red/yellow pheomelanin. The variation of skin color among individuals is mostly because of variation of the content of melanin in the skin. Skin with little or no melanin is almost white. Other factors influence skin color in a lesser degree, including the amount of blood in blood vessels (because of the color of blood), skin thickness and content of carotenoids in skin.
Melanin in synthesized in melanosomes which are organelles produced in melanocytes. Melanocytes are cells dedicated to this function that are present in the skin, hair follicles, and other structures of the body. The synthesis of melanin (also called" melanogenesis" and" melanization") involves a chain of enzyme-catalyzed chemical reactions and non-enzyme-catalyzed reactions. The main precursor to melanin is l-tyrosine. The first step of melanogenesis is the conversion of l-tyrosine to l-dopa; this is the first and rate-limiting step and is catalized by the enzyme tyrosinase. Other enzymes involved in the synthesis include tyrosinase-related protein 1 (trp1) and tyrosinase-related protein 2 (trp2); trp2 is also known as" dopachorome tautomerase" (dct). L-tyrosine is taken by the melanocytes from the intercellular medium, then transported to the melanosomes. L-tyrosine is also synthesized within the melanocytes from l-phenylalanine by the enzyme phenylalanine-hydroxylas (pah)
Melanosomes are transferred to keratinocytes (the most abundant cell type in the skin). Most of the melanin of skin is found in keratinocytes. Additionally, melanocytes interact with keratinocytes through chemical signaling.